4-CHLORO-N-METHYLFORMANILIDE

Base Information

• Chemical Name: 4-CHLORO-N-METHYLFORMANILIDE
• CAS No.: 26772-93-0
• Molecular Formula: C8H8 Cl N O
• Molecular Weight: 169.611
• Hs Code.: 2924299090
• Mol file: 26772-93-0.mol

Synonyms:Formanilide,4'-chloro-N-methyl- (6CI,8CI); 4-Chlorophenyl-N-methylformamide;N-Methyl-4-chloroformanilide; N-Methyl-N-(4-chlorophenyl)formamide; NSC 263785;p-Chloro-N-formyl-N-methylaniline; p-Chloro-N-methylformanilide

Chemical Property of 4-CHLORO-N-METHYLFORMANILIDE

Chemical Property:

• Vapor Pressure: 0.00135mmHg at 25°C
• Melting Point: 52 °C
• Boiling Point: 166 °C / 20mmHg
• PKA: -0.25±0.50(Predicted)
• Flash Point: 133.7°C
• PSA: 20.31000
• Density: 1.24g/cm³
• LogP: 2.56850
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

4'-Chloro-N-methylformanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-N-METHYLFORMANILIDE

There total 31 articles about 4-CHLORO-N-METHYLFORMANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

carbon dioxide (124-38-9,18923-20-1) + N-methyl(p-chloroaniline) (932-96-7) → N-(4-chlorophenyl)-N-methylformamide (26772-93-0)

Guidance literature:

With phenylsilane; In N,N-dimethyl-formamide; at 30 ℃; for 24h;

DOI:10.1039/c6cc03058k

Reference yield: 92.0%

N-(4-chlorophenyl)formamide (2617-79-0) + methyl iodide (74-88-4) → N-(4-chlorophenyl)-N-methylformamide (26772-93-0)

Guidance literature:

N-(4-chlorophenyl)formamide; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; Reflux; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00432

Reference yield: 89.0%

carbon monoxide (201230-82-2) + N-methyl(p-chloroaniline) (932-96-7) → N-(4-chlorophenyl)-N-methylformamide (26772-93-0)

Guidance literature:

With phenylsilane; C₁₉H₃₇N₂⁽¹⁺⁾*Br^(1-); In neat (no solvent); at 20 ℃; for 12h; under 3750.38 Torr; Autoclave;

DOI:10.1016/j.cattod.2020.01.030

upstream raw materials:

4-chloro-aniline

trimethyl orthoformate

formic acid

dimethyl sulfate

Downstream raw materials:

1-decyne

7-chloro-4-(4-chlorophenyl)-1-methylbenzo[f][1,4]-diazepine-2,3-dicarboxylic anhydride

(E)-1,2-Dichloro-N,N'-bis-(4-chloro-phenyl)-N,N'-dimethyl-ethene-1,2-diamine

N-(4-chlorophenyl)-N-cyclopropylmethylamine

Refernces

• 1、 Lin, Xiao-Tao,Matsumoto, Kazuhiro,Maegawa, Yoshifumi,Takeuchi, Katsuhiko,Fukaya, Norihisa,Sato, Kazuhiko,Inagaki, Shinji,Choi, Jun-Chul. "Immobilized Zn(OAc)2on bipyridine-based periodic mesoporous organosilica for N -formylation of amines with CO2and hydrosilanes". supporting information. p. 9501 - 9505. Retrieved 2021/06/14.
• 2、 Wu, Shanxuan,Huang, Zijun,Jiang, Xiaolin,Yan, Fachao,Li, Yuehui,Du, Chen-Xia. "Recyclable Oxofluorovanadate-Catalyzed Formylation of Amines by Reductive Functionalization of CO2 with Hydrosilanes". . p. 1763 - 1766. Retrieved 2021/03/01.