4-hydroxy-3-methoxymethamphetamine

Base Information

• Chemical Name: 4-hydroxy-3-methoxymethamphetamine
• CAS No.: 117652-28-5
• Molecular Formula: C11H17 N O2
• Molecular Weight: 195.261
• UNII: RBY3J6H4JW
• DSSTox Substance ID: DTXSID70922503
• Nikkaji Number: J510.151D
• Wikipedia: 4-Hydroxy-3-methoxymethamphetamine
• Wikidata: Q15634060
• Mol file: 117652-28-5.mol

Synonyms:4-Hydroxy-3-methoxymethamphetamine; 2-Methoxy-4-(2-(methylamino)propyl)phenol; 4,3-Hmm; Phenol, 2-methoxy-4-(2-(methylamino)propyl)-

Chemical Property of 4-hydroxy-3-methoxymethamphetamine

Chemical Property:

• Vapor Pressure: 0.000306mmHg at 25°C
• Boiling Point: 311.5°Cat760mmHg
• Flash Point: 142.2°C
• PSA: 41.49000
• Density: 1.044g/cm³
• LogP: 1.94210
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 195.125928785
• Heavy Atom Count: 14
• Complexity: 163

Purity/Quality:

98%min ^*data from raw suppliers

4-HYDROXY-3-METHOXYMETHAMPHETAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC(=C(C=C1)O)OC)NC

Technology Process of 4-hydroxy-3-methoxymethamphetamine

There total 4 articles about 4-hydroxy-3-methoxymethamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

C11H15NO2 → 4-Hydroxy-3-methoxymethamphetamine (117652-28-5)

Guidance literature:

C₁₁H₁₅NO₂; With sodium cyanoborohydride; In methanol; at 20 ℃; for 5h; Heating / reflux;

With hydrogenchloride; In 1,4-dioxane; methanol;

Reference yield:

1-(4-hydroxy-3-methoxyphenyl)2-propanone (2503-46-0) + methylamine hydrochloride (593-51-1) → 4-Hydroxy-3-methoxymethamphetamine (117652-28-5)

Guidance literature:

With sodium cyanoborohydride; In methanol; for 72h; Ambient temperature;

DOI:10.1002/(SICI)1096-9888(199711)32:11<1236::AID-JMS584>3.0.CO;2-K

Reference yield:

4-allylguaiacol (97-53-0) → 4-Hydroxy-3-methoxymethamphetamine (117652-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: HBr / 0 °C / anschliessendes Behandeln mit wss. HBr

2: methanol

With methanol; hydrogen bromide;

DOI:10.1039/jr9450000533

upstream raw materials:

4-(2-bromo-propyl)-2-methoxy-phenol

methylamine

1-(4-hydroxy-3-methoxyphenyl)2-propanone

methylamine hydrochloride

Downstream raw materials:

C₁₆H₂₅NO₄