Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, 2-(2,2-dimethyl-1,3-dioxa-6-aza-2-silacyclooct-6-yl)ethyl ester

Base Information

• Chemical Name: Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, 2-(2,2-dimethyl-1,3-dioxa-6-aza-2-silacyclooct-6-yl)ethyl ester
• CAS No.: 57966-38-8
• Molecular Formula: C18H28ClNO5Si
• Molecular Weight: 401.9571
• DSSTox Substance ID: DTXSID80206700
• Wikidata: Q83080563
• Mol file: 57966-38-8.mol

Synonyms:BRN 5999573;57966-38-8;Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, 2-(2,2-dimethyl-1,3-dioxa-6-aza-2-silacyclooct-6-yl)ethyl ester;1,1-Dimethyl-2,8-dioxa-5-hydroxyethyl-1-sila-5-azacyclooctane p-chlorophenoxy isobutyrate;C18H28ClNO5Si;C18-H28-Cl-N-O5-Si;DTXSID80206700;LS-124571

Chemical Property of Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, 2-(2,2-dimethyl-1,3-dioxa-6-aza-2-silacyclooct-6-yl)ethyl ester

Chemical Property:

• Vapor Pressure: 1.1E-08mmHg at 25°C
• Boiling Point: 461.2°Cat760mmHg
• Flash Point: 232.7°C
• Density: 1.17g/cm³
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 401.1425272
• Heavy Atom Count: 26
• Complexity: 443

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C(=O)OCCN1CCO[Si](OCC1)(C)C)OC2=CC=C(C=C2)Cl

Technology Process of Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, 2-(2,2-dimethyl-1,3-dioxa-6-aza-2-silacyclooct-6-yl)ethyl ester

There total 3 articles about Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, 2-(2,2-dimethyl-1,3-dioxa-6-aza-2-silacyclooct-6-yl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Clofibric acid (882-09-7) → 2-(4-Chloro-phenoxy)-2-methyl-propionic acid 2-(2,2-dimethyl-[1,3,6,2]dioxazasilocan-6-yl)-ethyl ester (57966-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / Heating

2: tetrahydrofuran / 3 h / Heating

In tetrahydrofuran;

Reference yield:

clofibryl chloride (5542-60-9) → 2-(4-Chloro-phenoxy)-2-methyl-propionic acid 2-(2,2-dimethyl-[1,3,6,2]dioxazasilocan-6-yl)-ethyl ester (57966-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / Heating

2: tetrahydrofuran / 3 h / Heating

In tetrahydrofuran;

Reference yield:

2,2-dimethyl-6-(2-hydroxyethyl)-1,3,6,2-dioxazasilocane (42959-18-2) + 2-(4-Chloro-phenoxy)-1-imidazol-1-yl-2-methyl-propan-1-one (60701-43-1) → 2-(4-Chloro-phenoxy)-2-methyl-propionic acid 2-(2,2-dimethyl-[1,3,6,2]dioxazasilocan-6-yl)-ethyl ester (57966-38-8)

Guidance literature:

In tetrahydrofuran; for 3h; Yield given; Heating;

upstream raw materials:

2,2-dimethyl-6-(2-hydroxyethyl)-1,3,6,2-dioxazasilocane

2-(4-Chloro-phenoxy)-1-imidazol-1-yl-2-methyl-propan-1-one

Clofibric acid

clofibryl chloride

Refernces