1,2-bis-(Hydroxymethyl)-o-carborane

Base Information

• Chemical Name: 1,2-bis-(Hydroxymethyl)-o-carborane
• CAS No.: 19610-37-8
• Molecular Formula: C4H16 B10 O2
• Molecular Weight: 204.28
• Mol file: 19610-37-8.mol

Synonyms:1,2-Bis(hydroxymethyl)-o-carborane;1,2-Bis(hydroxymethyl)carborane; Bis(hydroxymethyl)-o-carborane;Dihydroxymethyl-o-carborane; NSC 98987; o-Carboranedimethanol

Chemical Property of 1,2-bis-(Hydroxymethyl)-o-carborane

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1,2-BIS(HYDROXYMETHYL)-O-CARBORANE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Moderately toxic by ingestion and inhalation. A moderate eye irritant.
• Hazard Codes: Moderately toxic by ingestion and inhalation. A moderate eye irritant.

MSDS Files:

Total 1 MSDS from other Authors

Useful:

Technology Process of 1,2-bis-(Hydroxymethyl)-o-carborane

There total 6 articles about 1,2-bis-(Hydroxymethyl)-o-carborane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,2-dicarba-closo-dodecaborane(12) (16872-09-6) → 1,2-bis(hydroxymethyl)-ortho-carborane (19610-37-8) + (1'-hydroxymethyl)-1,2-dicarba-closo-dodecaborane (19610-34-5)

Guidance literature:

With tetrabutyl ammonium fluoride;

DOI:10.1002/ejic.201600117

Reference yield:

1.2-bis-(acetoxymethyl)-1.2-dicarba-closo-dodecaborane(12) (19610-38-9) + water (7732-18-5) → 1,2-bis(hydroxymethyl)-ortho-carborane (19610-37-8)

Guidance literature:

With hydrogen cation; In water; acidic hydrolysis;;

DOI:10.1021/ic50010a004

Reference yield:

methanol (67-56-1) + 1.2-bis-(acetoxymethyl)-1.2-dicarba-closo-dodecaborane(12) (19610-38-9) → 1,2-bis(hydroxymethyl)-ortho-carborane (19610-37-8)

Guidance literature:

With hydrogenchloride; In methanol; in boiling methanol containing small amounts of HCl;;

DOI:10.1021/ic50010a008

upstream raw materials:

lithium aluminium tetrahydride

1.2-bis-(acetoxymethyl)-1.2-dicarba-closo-dodecaborane⁽¹²⁾

1,2-dilithio-o-carborane

water

Downstream raw materials:

1,2-dicarba-closo-dodecaborane⁽¹²⁾

Refernces

• 1、 Tanaka, Tomohiro,Nishiura, Yukiko,Araki, Rikita,Saido, Takaomi,Abe, Ryo,Aoki, Shin. "11B NMR Probes of Copper(II): Finding and Implications of the Cu2+-Promoted Decomposition of ortho-Carborane Derivatives". . p. 1819 - 1834. Retrieved 2016/05/02.
• 2、 Fein, Marvin M.,Grafstein, Daniel,Paustian, John E.,Bobinski, Jack,Lichstein, Bernard M.,Mayes, Nathan,Schwartz, Nelson N.,Cohen, Murray S.. "Carboranes. II. The preparation of 1- and 1,2-substituted carboranes". . p. 1115 - 1119. Retrieved 2008/10/08.