Chemical Property of Itopride hydrochloride
Chemical Property:
- Appearance/Colour:white or pale brownish crystal
- Vapor Pressure:1.6E-10mmHg at 25°C
- Melting Point:194-195 °C
- Boiling Point:510.1 °C at 760 mmHg
- Flash Point:262.3 °C
- PSA：60.03000
- LogP:3.76710
- Storage Temp.:-20?C Freezer
- Solubility.:H2O: ≥48mg/mL
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:9
- Exact Mass:394.1659350
- Heavy Atom Count:27
- Complexity:411
- Purity/Quality:
-
99% *data from raw suppliers
Itopride Hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
N
- Hazard Codes:N
- Statements:
50
- Safety Statements:
61
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CN(C)CCOC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC)OC.Cl
- Recent ClinicalTrials:Long-term Safety and Efficacy of Itopride Hydrochloride (HCl) in Patients Suffering From Functional Dyspepsia
- Recent EU Clinical Trials:Functional Dyspepsia: validation of a questionnaire for symptom assessment in patients suffering from Postprandial Distress Syndrome (Functional Dyspepsia): assessment of sensitivity to change in PDS symptom severity in an interventional study
-
Description
Itopride, a gastroprokinetic benzamide derivative was launched in
Japan for the relief of gastrointestinal symptoms in patients with chronic gastritis.
ltopride is a dopamine D2-receptor antagonist that stimulates acetylcholine (Ach)
release on the postganglionic cholinergic neurons to cause Ach accumulation at
muscarinic receptors and, therefore, enhances Ach-induced gastric contractions. In
animal models, itopride was reported to increase GI transit and gastric emptying.
-
Uses
Dopamine D2-receptor antagonist with anticholinesterase activity. Gastroprokinetic Dopamine D2 receptor blockade,acetylcholinesterase inhibitor Anti-Spasmodics
