6-Methoxy-2-phenylquinoline-4-carboxylic acid

Base Information

• Chemical Name: 6-Methoxy-2-phenylquinoline-4-carboxylic acid
• CAS No.: 32795-58-7
• Molecular Formula: C17H13 N O3
• Molecular Weight: 279.295
• European Community (EC) Number: 636-507-4
• NSC Number: 40829
• DSSTox Substance ID: DTXSID90285182
• Wikidata: Q82020463
• Mol file: 32795-58-7.mol

Synonyms:6-methoxy-2-phenylquinoline-4-carboxylic acid;32795-58-7;6-Methoxy-2-Phenyl-4-Quinolinecarboxylic Acid;6-METHOXYCINCHOPHEN;6-Methoxy-2-phenyl-quinoline-4-carboxylic acid;NSC40829;Enamine_005210;Oprea1_857781;SCHEMBL245078;DTXSID90285182;HMS1408M18;NSC-40829;STK209840;AKOS001063531;SB70580;IDI1_007797;6-methoxy-2-phenylquinoline-4-carboxylicacid;CS-0219492;FT-0748075;EN300-04172;Z56887640

Chemical Property of 6-Methoxy-2-phenylquinoline-4-carboxylic acid

Chemical Property:

• Vapor Pressure: 2.37E-10mmHg at 25°C
• Boiling Point: 488.4°C at 760 mmHg
• Flash Point: 249.1°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 279.08954328
• Heavy Atom Count: 21
• Complexity: 367

Purity/Quality:

98%min ^*data from raw suppliers

6-METHOXY-2-PHENYL-4-QUINOLINECARBOXYLIC ACID Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)N=C(C=C2C(=O)O)C3=CC=CC=C3

Technology Process of 6-Methoxy-2-phenylquinoline-4-carboxylic acid

There total 7 articles about 6-Methoxy-2-phenylquinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzaldehyde (100-52-7) + 4-methoxy-aniline (104-94-9) + 2-oxo-propionic acid (127-17-3) → 2-phenyl-6-methoxyquinoline-4-carboxylic acid (32795-58-7)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; for 0.05h; Microwave irradiation; Green chemistry;

DOI:10.1002/jhet.3848

Reference yield: 57.0%

5-methoxyisatine (39755-95-8) + acetophenone (98-86-2) → 2-phenyl-6-methoxyquinoline-4-carboxylic acid (32795-58-7)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 125 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.9b00115

Reference yield: 57.0%

→ 2-phenyl-6-methoxyquinoline-4-carboxylic acid (32795-58-7)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 125 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;

upstream raw materials:

[4-(benzylideneamino)phenyl]methanol

2-oxo-propionic acid

benzaldehyde

4-methoxy-aniline

Downstream raw materials:

2-phenyl-6-methoxyquinoline

6-hydroxy-2-phenyl-quinoline-4-carboxylic acid

6-methoxy-2-phenyl-quinoline-4-carbonyl chloride

6-hydroxy-2-phenylquinoline