distamin

Base Information

• Chemical Name: distamin
• CAS No.: 65361-29-7
• Molecular Formula: C24H32 N8 O4
• Molecular Weight: 496.569
• Mol file: 65361-29-7.mol

Synonyms:Distamin

Chemical Property of distamin

Chemical Property:

• Vapor Pressure: 1.38E-17mmHg at 25°C
• Boiling Point: 665.7°C at 760 mmHg
• Flash Point: 356.4°C
• PSA: 137.92000
• Density: 1.3g/cm³
• LogP: 2.64290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of distamin

There total 16 articles about distamin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(tert-butoxycarbonyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid (77716-11-1) → C24H32N8O4 (65361-29-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 4.3 mg / EDCI; DMAP / dimethylformamide / 16 h / 25 °C

2.1: 98 percent / aq. LiOH / tetrahydrofuran; methanol / 8 h / 60 °C

3.1: EDCI; DMAP / dimethylformamide / 1 h / 25 °C

3.2: 68 percent / dimethylformamide / 13 h / 25 °C

4.1: HCl / ethyl acetate / 1 h / 25 °C

5.1: 3.8 mg / CDI / tetrahydrofuran / 3 h / 25 °C

With hydrogenchloride; dmap; lithium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ja994192d

Reference yield:

N-[3-(dimethylamino)propyl]-1-methyl-4-{[(1-methyl-4-nitro-1H-pyrrol-2-yl)carbonyl]amino}-1H-pyrrole-2-carboxamide (65361-31-1) → C24H32N8O4 (65361-29-7)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethanol / 4 h / 20 °C / atmospheric pressure

2: 1.050 g / N-methylmorpholine / tetrahydrofuran

3: H₂ / Pd/C / methanol / 5 h / 20 °C / atmospheric pressure

4: ethanol / 48 h / Heating

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;

DOI:10.1021/jm031089x

Reference yield:

1-methyl-4-nitropyrrole-2-carboxylic acid methyl ester (13138-76-6) → C24H32N8O4 (65361-29-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / H₂ / 10percent Pd/C / methanol / 3 h / Ambient temperature

2: 1.) 2 M aq. NaOH / 1.) MeOH, 0 deg C, 6 h, 2.) MeOH, ether, RT, 30 min

3: 67 percent / EDCl / dimethylformamide / 1 h

4: dimethylformamide / 4 h / 55 °C

With sodium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ja00095a001

upstream raw materials:

4-{[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-N-[3-(dimethylamino)propyl]-1-methyl-1H-pyrrole-2-carboxamide

4-Formylamino-1-methyl-1H-pyrrole-2-carboxylic acid 4-oxo-4H-benzo[d][1,2,3]triazin-3-yl ester

3-(1-methyl-4-(1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido)pyrrole-2-carboxamido)dimethylaminopropane

formic acid ethyl ester

Refernces

• 1、 Khalaf, Abedawn I.,Waigh, Roger D.,Drummond, Allan J.,Pringle, Breffni,McGroarty, Ian,Skellern, Graham G.,Suckling, Colin J.. "Distamycin Analogues with Enhanced Lipophilicity: Synthesis and Antimicrobial Activity". . p. 2133 - 2156. Retrieved 2007/10/03.