Ethanol, 2-(4-methylphenyl)amino-

Base Information

• Chemical Name: Ethanol, 2-(4-methylphenyl)amino-
• CAS No.: 2933-74-6
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• Hs Code.: 2921499090
• Mol file: 2933-74-6.mol

Synonyms:Ethanol, 2-[(4-methylphenyl)amino]-;N,N-(2-Hydroxyethyl)-p-toluidine;2-p-Tolylamino-ethanol;N-hydroxyethyl-p-toluidine;

Chemical Property of Ethanol, 2-(4-methylphenyl)amino-

Chemical Property:

• Vapor Pressure: 0.00119mmHg at 25°C
• Melting Point: 42.5°C
• Refractive Index: 1.588
• Boiling Point: 286.999 °C at 760 mmHg
• Flash Point: 140.541 °C
• PSA: 32.26000
• Density: 1.086 g/cm³
• LogP: 1.47220

Purity/Quality:

98%min ^*data from raw suppliers

2-p-Tolylaminoethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-p-Tolylaminoethanol is derived from 1,2-Ethylene Glycol (E890140), which is used in the synthesis of nanotubes (1) and nanocables (2). Also primarily used in the synthesis of polyester fibers and PET (polyethylene terephthalate) bottling products. Also used in the study of phosphocholine membranes through the synthesis of polyethylene glycol (4). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.

Technology Process of Ethanol, 2-(4-methylphenyl)amino-

There total 25 articles about Ethanol, 2-(4-methylphenyl)amino- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-tolyl iodide (624-31-7) + ethanolamine (141-43-5) → 2-[(4-methylphenyl)amino]-ethanol (2933-74-6)

Guidance literature:

With copper(l) iodide; 1-(5,6,7,8-tetrahydroquinolin-8-yl)ethan-1-one; caesium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 8h; Inert atmosphere;

DOI:10.1039/b821212k

Reference yield: 97.0%

para-bromotoluene (106-38-7) + ethanolamine (141-43-5) → 2-[(4-methylphenyl)amino]-ethanol (2933-74-6)

Guidance literature:

With copper(l) chloride; potassium hydroxide; at 90 ℃; for 8h; Neat (no solvent);

DOI:10.1016/j.tetlet.2011.12.130

Reference yield: 95.0%

para-chlorotoluene (106-43-4) + ethanolamine (141-43-5) → 2-[(4-methylphenyl)amino]-ethanol (2933-74-6)

Guidance literature:

With copper(l) iodide; C₁₄H₁₆N₂O; caesium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.0c02672

upstream raw materials:

oxirane

p-toluidine

N-(p-Tolyl)carbamidsaeure-β-chlorethylester

2-chloro-ethanol

Downstream raw materials:

3-p-tolyl-oxazolidine

2-methyl-3-p-tolyl-oxazolidine

N'-benzoyl-N-(2-hydroxy-ethyl)-N-p-tolyl-thiourea

4-p-tolyl-morpholin-3-one

Refernces

• 1、 -. "Ligand compound for copper catalyzed aryl halide coupling reaction, catalytic system and coupling reaction". Paragraph 0086-0091; 0094-0095. . Retrieved 2021/05/29.
• 2、 Guo, Hui,Hao, Jia,Sun, Tingting,Wang, Zuoyao,Cao, Jian,Zhang, Guobao. "Green synthesis of N-(2-hydroxyethyl)anilines by the selective alkylation reaction in H2O". . p. 1 - 6. Retrieved 2020/07/21.