1,4-bis(4-methylphenyl)piperazine

Base Information

• Chemical Name: 1,4-bis(4-methylphenyl)piperazine
• CAS No.: 3367-48-4
• Molecular Formula: C18H22N2
• Molecular Weight: 266.386
• Mol file: 3367-48-4.mol

Synonyms:

Chemical Property of 1,4-bis(4-methylphenyl)piperazine

Chemical Property:

• Vapor Pressure: 5.39E-08mmHg at 25°C
• Boiling Point: 441.6°Cat760mmHg
• Flash Point: 201.4°C
• Density: 1.067g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-bis(4-methylphenyl)piperazine

There total 20 articles about 1,4-bis(4-methylphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

piperazine (110-85-0) + para-bromotoluene (106-38-7) → 1,4-bis(4-methylphenyl)piperazine (3367-48-4)

Guidance literature:

With potassium 2-methylbutan-2-olate; [(1,3-(2,6-iPr₂C₆H₃)2-1,3-dihydroimidazol-2-ylidene)PdCl₂]2; In 1,2-dimethoxyethane; at 80 ℃; for 0.8h;

DOI:10.1021/ol0260831

Reference yield: 88.0%

p-toluidine (106-49-0,12221-03-3) + ethylene glycol (107-21-1) → 2-[(4-methylphenyl)amino]-ethanol (2933-74-6) + 5-methyl-1H-indole (614-96-0) + 1,4-bis(4-methylphenyl)piperazine (3367-48-4) + N,N'-di-p-tolylethylenediamine (4693-68-9)

Guidance literature:

With palladium on activated charcoal; zinc(II) oxide; In water; at 150 ℃; for 24h; Reagent/catalyst; Temperature; Time; Sealed tube;

DOI:10.1016/j.tet.2017.08.006

Reference yield: 81.0%

piperazine (110-85-0) + para-chlorotoluene (106-43-4) → (4-methylphenyl)piperazine (39593-08-3) + 1,4-bis(4-methylphenyl)piperazine (3367-48-4)

Guidance literature:

piperazine; With [2,2]bipyridinyl; nickel diacetate; sodium hydride; tert-Amyl alcohol; In tetrahydrofuran; at 65 ℃; for 2h;

para-chlorotoluene; With styrene; In tetrahydrofuran; at 65 ℃; for 6.5h;

DOI:10.1016/S0040-4020(02)00750-0

upstream raw materials:

oxirane

p-toluidine

2-[(4-methylphenyl)amino]-ethanol

N, N’-dimethyl-N,N’-di-p-tolylethane-1,2-diamine

Refernces

• 1、 Llabres-Campaner, Pedro Juan,Ballesteros-Garrido, Rafael,Ballesteros, Rafael,Abarca, Belén. "Straight Access to Indoles from Anilines and Ethylene Glycol by Heterogeneous Acceptorless Dehydrogenative Condensation". supporting information. p. 521 - 526. Retrieved 2018/01/01.
• 2、 Kurandina,Eliseenkov,Khaibulova,Petrov,Boyarskiy. "Copper-catalyzed C-N bond cross-coupling of aryl halides and amines in water in the presence of ligand derived from oxalyl dihydrazide: Scope and limitation". . p. 7931 - 7937. Retrieved 2015/09/15.