2-Furanmethanamine, N-methyl-

Base Information

• Chemical Name: 2-Furanmethanamine, N-methyl-
• CAS No.: 4753-75-7
• Molecular Formula: C6H9 N O
• Molecular Weight: 111.144
• Hs Code.: 29321900
• European Community (EC) Number: 225-278-2
• NSC Number: 78427
• UNII: 8NA5T44A2N
• DSSTox Substance ID: DTXSID8063597
• Nikkaji Number: J37.035E
• Wikidata: Q81990856
• ChEMBL ID: CHEMBL4439478
• Mol file: 4753-75-7.mol

Synonyms:N-Methylfurfurylamine;4753-75-7;1-(furan-2-yl)-N-methylmethanamine;2-Furanmethanamine, N-methyl-;Furfurylamine, N-methyl-;N-Furfuryl-N-methylamine;(2-furylmethyl)methylamine;(furan-2-ylmethyl)(methyl)amine;methylfurfurylamine;(2-furanylmethyl)methylamine;8NA5T44A2N;[(furan-2-yl)methyl](methyl)amine;EINECS 225-278-2;NSC 78427;NSC-78427;2-Furyl-N-methylmethanamine;N-methyl-2-Furanmethanamine;NSC78427;N-Methyl-N-furfurylamine;furan-2-ylmethylmethylamine;UNII-8NA5T44A2N;N-Methylfurfurylamine, 95%;(Furan-2-ylmethyl)methylamine;furan-2-ylmethyl-methyl-amine;SCHEMBL172653;2-Furyl-N-methylmethanamine #;SCHEMBL2086456;SCHEMBL2086459;CHEMBL4439478;DTXSID8063597;1-(2-furyl)-N-methylmethanamine;HMS1719G19;MFCD00020961;AKOS000264147;SDCCGMLS-0065658.P001;BB 0257378;CS-0187786;FT-0683135;EN300-09804;1X-0939;A872124;Z57051072

Chemical Property of 2-Furanmethanamine, N-methyl-

Chemical Property:

• Vapor Pressure: 4.11mmHg at 25°C
• Refractive Index: n20/D 1.471(lit.)
• Boiling Point: 149°Cat760mmHg
• PKA: 8.96±0.10(Predicted)
• Flash Point: 34°C
• PSA: 25.17000
• Density: 0.976g/cm³
• LogP: 1.38990
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 111.068413911
• Heavy Atom Count: 8
• Complexity: 65.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(2-Furylmethyl)-N-methylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CNCC1=CC=CO1
• Uses: Intermediate. N-Methylfurfurylamine may be used in the synthesis of cis -α-[2-[(2-furanylmet hyl)methylamino]cyclohexyl]-benzenemethanol.

Technology Process of 2-Furanmethanamine, N-methyl-

There total 10 articles about 2-Furanmethanamine, N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-(2-furylmethyl)-1H-imidazole-1-carboxamide → N-methyl-2-furanmethanamine (4753-75-7)

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 20 - 66 ℃;

Reference yield: 60.0%

furfural (98-01-1) + methylamine hydrochloride (593-51-1) → N-methyl-2-furanmethanamine (4753-75-7)

Guidance literature:

methylamine hydrochloride; With potassium carbonate; In methanol; at 0 ℃; for 0.5h; Inert atmosphere;

furfural; In methanol; at 0 - 20 ℃; Inert atmosphere;

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b03172

Reference yield:

C11H17NO3 → N-methyl-2-furanmethanamine (4753-75-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1039/c7ob00593h

upstream raw materials:

furfural

2-bromomethylfuran

N-methylfurfurylidenamine

N-methylfuran-2-carboxamide

Downstream raw materials:

1-phenyl-2-(furfurylmethylamino)ethanol

1-(3,4-dimethoxyphenyl)-2-furfuryl(methyl)aminoethanol hydrochloride

1-phenyl-2-(furfurylmethylamino)ethanol oxalate

2-furfuryl(methyl)amino-1-(4-methoxyphenyl)ethanol oxalate

Refernces

• 1、 -. "Synthesis method of N-methylamine compound". Paragraph 0069-0072. . Retrieved 2018/09/08.
• 2、 McPherson, Christopher G.,Caldwell, Nicola,Jamieson, Craig,Simpson, Iain,Watson, Allan J. B.. "Amidation of unactivated ester derivatives mediated by trifluoroethanol". supporting information. p. 3507 - 3518. Retrieved 2017/04/26.