N-methylfuran-2-carboxamide

Base Information

• Chemical Name: N-methylfuran-2-carboxamide
• CAS No.: 21402-85-7
• Molecular Formula: C6H7NO2
• Molecular Weight: 125.127
• DSSTox Substance ID: DTXSID20391705
• Nikkaji Number: J475.085C
• Wikidata: Q82189359
• Mol file: 21402-85-7.mol

Synonyms:N-methylfuran-2-carboxamide;N-methyl-2-furamide;21402-85-7;2-Furancarboxamide, N-methyl-;Methyloxathylamin;SCHEMBL353706;DTXSID20391705;AKOS008932898;AK-830/25033016

Chemical Property of N-methylfuran-2-carboxamide

Chemical Property:

• PSA: 42.24000
• LogP: 1.03010
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 125.047678466
• Heavy Atom Count: 9
• Complexity: 114

Purity/Quality:

N-METHYL-2-FURAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(=O)C1=CC=CO1

Technology Process of N-methylfuran-2-carboxamide

There total 16 articles about N-methylfuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

furan-2-carboxylic acid amide (609-38-1) + bis(1-methyl-1-phenylethyl)peroxide (80-43-3) → N-methylfuran-2-carboxamide (21402-85-7)

Guidance literature:

With copper(l) chloride; In chlorobenzene; at 130 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol401362k

Reference yield: 83.0%

N-methoxy-N-methyl-2-furancarboxamide (95091-92-2) → N-methylfuran-2-carboxamide (21402-85-7)

Guidance literature:

With N¹,N¹,N¹²,N¹²-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a:2,1'-c][1,4]diazepine-2,12-diamine; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1055/s-2008-1078240

Reference yield: 82.0%

2-furaldehyde oxime (1121-47-7) + methanol (67-56-1) → N-methylfuran-2-carboxamide (21402-85-7)

Guidance literature:

With C₅₄H₄₃ClN₃P₂Ru⁽¹⁺⁾*F₆P^(1-); caesium carbonate; In toluene; at 150 ℃; for 48h; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1002/adsc.201900962

upstream raw materials:

2-furancarbonyl chloride

methylamine

2-furoic acid methyl ester

C₂H₇AlClN

Downstream raw materials:

N-methyl-2-furanmethanamine

dimethyl-(α-phenylsulfanyl-furfuryliden)-ammonium; iodide

N-methylfuran-2-carboximidoyl chloride

Furan-2-carboxylic acid (diphenyl-phosphinoylmethyl)-methyl-amide