2-(Bromomethyl)furan

Base Information

• Chemical Name: 2-(Bromomethyl)furan
• CAS No.: 4437-18-7
• Molecular Formula: C5H5 Br O
• Molecular Weight: 160.998
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID50404771
• Nikkaji Number: J906.778G
• Wikidata: Q72447134
• Mol file: 4437-18-7.mol

Synonyms:2-(bromomethyl)furan;4437-18-7;2-Bromomethyl-furan;2-bromomethylfuran;Furan, 2-(bromomethyl)-;bromomethylfuran;furfuryl bromide;2-furylbromomethane;2-bromomethyl furan;SCHEMBL538112;DTXSID50404771;CEFVCNWQCJCMHZ-UHFFFAOYSA-N;AKOS016007411;AM100827;FT-0698420;A854617

Chemical Property of 2-(Bromomethyl)furan

Chemical Property:

• Vapor Pressure: 4.01mmHg at 25°C
• Refractive Index: 1.5380 (estimate)
• Boiling Point: 155 ºC
• Flash Point: 47 ºC
• PSA: 13.14000
• Density: 1.582
• LogP: 2.17450
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 159.95238
• Heavy Atom Count: 7
• Complexity: 56

Purity/Quality:

98%Min ^*data from raw suppliers

2-(Bromomethyl)furan ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=COC(=C1)CBr

Technology Process of 2-(Bromomethyl)furan

There total 12 articles about 2-(Bromomethyl)furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-methylfuran (534-22-5) → 2-bromomethylfuran (4437-18-7)

Guidance literature:

With N-Bromosuccinimide; trityl tetrafluoroborate; In dichloromethane; at 20 ℃; chemoselective reaction; Irradiation; Inert atmosphere;

DOI:10.1002/adsc.201800788

Reference yield: 91.0%

(2-furyl)methyl alcohol (98-00-0,25212-86-6,93793-62-5) + carbon tetrabromide (558-13-4) + pyrographite (7440-44-0) → 2-bromomethylfuran (4437-18-7)

Guidance literature:

With triphenylphosphine; In hexane; dichloromethane;

Reference yield: 91.0%

(2-furyl)methyl alcohol (98-00-0,25212-86-6,93793-62-5) + charcoal + carbon tetrabromide (558-13-4) → 2-bromomethylfuran (4437-18-7)

Guidance literature:

With triphenylphosphine; In hexane; dichloromethane;

upstream raw materials:

2-methylfuran

(2-furyl)methyl alcohol

ethyl-furfuryl-methyl-amine

bromocyane

Downstream raw materials:

2,6-difurfuryl-phenol

furan-2-ylmethanamine

bis((furan-2-yl)methyl)amine

1,4-dihydro-1,4-epoxynaphthalen-1-ylmethyl o-bromophenyl ether

Refernces

• 1、 Mekonnen Sanka, Bruktawit,Mamo Tadesse, Dereje,Teju Bedada, Endale,Mengesha, Ephriem T.,Babu G., Neelaiah. "Design, synthesis, biological screening and molecular docking studies of novel multifunctional 1,4-di (aryl/heteroaryl) substituted piperazine derivatives as potential antitubercular and antimicrobial agents". . . Retrieved 2022/01/20.
• 2、 -. "Aryl imidazole derivative and application thereof". Paragraph 0463-0465. . Retrieved 2021/06/23.