2933-74-6

Basic information

• Product Name: Ethanol, 2-(4-methylphenyl)amino-
• Synonyms: Ethanol, 2-(4-methylphenyl)amino-;2-[(4-Methylphenyl)amino]ethanol
• CAS NO: 2933-74-6
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• Mol File: 2933-74-6.mol
• Article Data: 30

Chemical Properties

• Melting Point: 42.5°C
• Boiling Point: 273.23°C (rough estimate)
• Flash Point: 140.541 °C
• Appearance: /
• Density: 1.0406 (rough estimate)
• Vapor Pressure: 0.00119mmHg at 25°C
• Refractive Index: 1.5675 (estimate)
• CAS DataBase Reference: Ethanol, 2-(4-methylphenyl)amino-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-(4-methylphenyl)amino-(2933-74-6)
• EPA Substance Registry System: Ethanol, 2-(4-methylphenyl)amino-(2933-74-6)

Safety Data

• Hazardous Substances Data: 2933-74-6(Hazardous Substances Data)

Usage

Uses

2-p-Tolylaminoethanol is derived from 1,2-Ethylene Glycol (E890140), which is used in the synthesis of nanotubes (1) and nanocables (2). Also primarily used in the synthesis of polyester fibers and PET (polyethylene terephthalate) bottling products. Also used in the study of phosphocholine membranes through the synthesis of polyethylene glycol (4). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.

InChI:InChI=1/C9H13NO/c1-8-2-4-9(5-3-8)10-6-7-11/h2-5,10-11H,6-7H2,1H3

Upstream product

• 75-21-8 oxirane 
• 106-49-0 p-toluidine 
• 107-07-3 2-chloro-ethanol 
• 66889-71-2 N-(2-hydroxyethyl)-2-(4-methylphenoxy)acetamide 
• 26583-58-4 β-(2-methylphenoxy)ethylamine 
• 107-21-1 ethylene glycol 
• 624-31-7 4-tolyl iodide 
• 141-43-5 ethanolamine 
• 106-43-4 para-chlorotoluene 
• 5198-46-9 3-(4-methylphenyl)-2-oxazolidinone 
• 106-38-7 para-bromotoluene 
• 540-51-2 2-bromoethanol 
• 940-64-7 2-(4-methylphenoxy)acetic acid 
• 96-49-1 [1,3]-dioxolan-2-one 

Downstream Products

• 138416-29-2 N-(2-hydroxy-ethyl)-N-p-tolyl-urea 
• 3367-48-4 1,4-bis(4-methylphenyl)piperazine 
• 54472-50-3 N-(2-bromo-ethyl)-p-toluidine; hydrobromide 
• 858844-88-9 N'-benzoyl-N-(2-hydroxy-ethyl)-N-p-tolyl-thiourea 
• 22746-90-3 3-p-tolyl-oxazolidine 
• 71472-58-7 3,4-dihydro-7-methyl-2H-1,4-benzoxazine 
• 1246521-07-2 C₁₁H₁₆N₂O₂ 
• 1246521-06-1 C₁₉H₂₂N₂O₄ 
• 1246519-10-7 C₂₀H₂₃N₅O₃ 
• 1246521-05-0 C₁₇H₁₉NO₃ 
• 62131-56-0 N-p-Tolyl-2-(p-nitrophenoxy)-ethylamin 
• 38201-24-0 N-(4-methylphenyl)aziridine 
• 80077-16-3 N,N-Dimethyl-N'-(3-p-tolyl-[1,3,2]oxazaphospholidin-2-yl)-benzene-1,4-diamine 

Relevant articles and documents

Ligand compound for copper catalyzed aryl halide coupling reaction, catalytic system and coupling reaction

The invention provides a ligand compound capable of being used for copper catalyzed aryl halide coupling reaction, the ligand compound is a three-class compound containing a 2-(substituted or non-substituted) aminopyridine nitrogen-oxygen group, and the invention also provides a catalytic system for the aryl halide coupling reaction. Thecatalytic system comprises a copper catalyst, a compound containing a 2-(substituted or non-substituted) aminopyridine nitrogen-oxygen group adopted as a ligand, alkali and a solvent, and meanwhile, the invention also provides a system for the aryl halide coupling reaction adopting the catalyst system. The compound containing the 2-(substituted or non-substituted) aminopyridine nitrogen oxygen group can be used as the ligand for the copper catalyzed aryl chloride coupling reaction, and the ligand is stable under a strong alkaline condition and can well maintain catalytic activity when being used for the copper-catalyzed aryl chloride coupling reaction. In addition, the copper catalyst adopting the compound as the ligand can particularly effectively promote coupling of copper catalyzed aryl chloride and various nucleophilic reagents which are difficult to generate under conventional conditions, C-N, C-O and C-S bonds are generated, and numerous useful small molecule compounds are synthesized. Therefore, the aryl halide coupling reaction has a very good large-scale application prospect by adopting the copper catalysis system of the ligand.

METHODS FOR PREPARING BENZOXAZINES

A method is provided for preparing a compound / the method comprising carrying out the following reaction: Formula (i); Formula (ii) where: R10 is hydrogen or a hydroxy protecting group; PG is an amine protecting group; and q is 1 where PG is a

CuI/2-Aminopyridine 1-Oxide Catalyzed Amination of Aryl Chlorides with Aliphatic Amines

A class of 2-aminopyridine 1-oxides are discovered to be effective ligands for the Cu-catalyzed amination of less reactive (hetero)aryl chlorides. A wide range of functionalized (hetero)aryl chlorides reacted with various aliphatic amines to afford the desired products in good to excellent yields under the catalyst of CuI/2-aminopyridine 1-oxides. Furthermore, the catalyst system worked well for the coupling of cyclic secondary amines and N-methyl benzylamine with (hetero)aryl chlorides.