5-fluoro-8-methoxyquinoline

Base Information

• Chemical Name: 5-fluoro-8-methoxyquinoline
• CAS No.: 439-88-3
• Molecular Formula: C₁₀H₈FNO
• Molecular Weight: 177.178
• Hs Code.: 2933499090
• Mol file: 439-88-3.mol

Synonyms:5-fluoro-8-methoxyquinoline

Chemical Property of 5-fluoro-8-methoxyquinoline

Chemical Property:

• Melting Point: 38.0 to 42.0 °C
• Boiling Point: 147°C/9mmHg(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: soluble in Methanol

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-8-methoxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Fluoro-8-methoxyquinoline is used as a reactant in the cobalt catalyled hydrogenation of quinolines and related N-heteroarenes.

Technology Process of 5-fluoro-8-methoxyquinoline

There total 3 articles about 5-fluoro-8-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 5,8-Difluoroquinoline (16650-32-1) → 5-methoxy-8-fluoroquinoline + 5-fluoro-8-methoxyquinoline (439-88-3)

Guidance literature:

methanol; With sodium; In ammonia; at 240 ℃;

5,8-Difluoroquinoline; In ammonia; dimethyl sulfoxide; at 298 ℃; for 2h;

DOI:10.1016/j.jfluchem.2005.08.010

Reference yield:

4-fluoro-1-methoxy-2-nitrobenzene (445-83-0) → 5-fluoro-8-methoxyquinoline (439-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel / Hydrogenation

2: iron (II)-sulfate; boric acid; nitrobenzene / Erhitzen des Reaktiongemisches mit konz. Schwefelsaeure

With boric acid; nickel; iron(II) sulfate; nitrobenzene;

DOI:10.1021/jo01136a009

Reference yield:

5-fluoro-2-methoxy-aniline (1978-39-8) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 5-fluoro-8-methoxyquinoline (439-88-3)

Guidance literature:

With boric acid; iron(II) sulfate; nitrobenzene; Erhitzen des Reaktiongemisches mit konz. Schwefelsaeure;

DOI:10.1021/jo01136a009

upstream raw materials:

5-fluoro-2-methoxy-aniline

glycerol

methanol

5,8-Difluoroquinoline

Downstream raw materials:

8-methoxyquinoline

5-fluoro-8-quinolinol