3-Ethoxyacrylic acid

Base Information

• Chemical Name: 3-Ethoxyacrylic acid
• CAS No.: 6192-01-4
• Molecular Formula: C5H8 O3
• Molecular Weight: 116.117
• Hs Code.: 2918990090
• European Community (EC) Number: 695-656-3
• NSC Number: 364201
• Nikkaji Number: J829.453D
• Wikidata: Q76310775
• Mol file: 6192-01-4.mol

Synonyms:3-Ethoxyacrylic acid;6192-01-4;(E)-3-Ethoxyacrylic acid;3-ethoxyprop-2-enoic acid;14674-80-7;3-Ethoxyacrylicacid;3-Ethyoxyacrylic acid;(E)-3-ethoxyprop-2-enoic acid;(2E)-3-ethoxyprop-2-enoic acid;(2E)-3-Ethoxyacrylic acid;2-Propenoic acid, 3-ethoxy-, (2E)-;3-Ethoxy-2-propenoic acid;MFCD01566841;NSC364201;(E)-3-ethoxy-acrylic acid;3-ethoxyacrylic acid, AldrichCPR;AMY9262;BCP05609;2-Propenoic acid,3-ethoxy-,(2E)-;4-METHYL-2-PHENYLACETOPHENONE;AKOS006228816;CS-W019195;NSC-364201;AS-11132;AS-57294;CS-0166780;EN300-125926;EN300-307457;J-512412

Chemical Property of 3-Ethoxyacrylic acid

Chemical Property:

• Melting Point: 109 °C
• Boiling Point: 70-140 °C(Press: 1 Torr)
• PKA: 4.86±0.10(Predicted)
• PSA: 46.53000
• Density: 1.1100 g/cm3
• LogP: 0.62120
• Storage Temp.: 2-8°C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 116.047344113
• Heavy Atom Count: 8
• Complexity: 95.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Ethoxyacrylicacid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC=CC(=O)O
• Isomeric SMILES: CCO/C=C/C(=O)O

Technology Process of 3-Ethoxyacrylic acid

There total 21 articles about 3-Ethoxyacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(3E)-1,1,1-trichloro-4-ethoxybut-3-en-2-one (59938-07-7) → (E)-3-ethoxyprop-2-enoic acid (6192-01-4,19483-24-0,14674-80-7)

Guidance literature:

With potassium hydroxide; In diethyl ether; water; for 2h;

Reference yield: 79.0%

orthoformic acid triethyl ester (122-51-0) → 3-ethoxyprop-2-enoic acid (6192-01-4)

Guidance literature:

With acetic anhydride;

Reference yield: 68.0%

ethyl 3-ethoxyacrylate (1001-26-9) → 3-ethoxyprop-2-enoic acid (6192-01-4)

Guidance literature:

With sodium hydroxide;

DOI:10.1016/0040-4020(95)00367-H

upstream raw materials:

(2E)-3-ethoxyprop-2-enoyl chloride

ethyl 3-ethoxyacrylate

ethanol

C₉H₁₇NO₂

Downstream raw materials:

2-hydroxy-benzene-1,3,5-tricarboxylic acid triethyl ester

3-ethoxyacryloyl chloride

ethanol

acetaldehyde

Refernces

• 1、 Bergé, Justine,Bonduelle, Colin,Boudot, Clotilde,Bourgeade-Delmas, Sandra,Boutet-Robinet, Elisa,Brossas, Jean-Yves,Corvaisier, Sophie,Courtioux, Bertrand,Deraeve, Céline,Destere, Alexandre,Fairlamb, Alan H.,Malzert-Fréon, Aurélie,Mazier, Dominique,Milne, Rachel,Paris, Luc,Pedron, Julien,Pinault, Emilie,Pratviel, Geneviève,Since, Marc,Sournia-Saquet, Alix,Stigliani, Jean-Luc,Tronnet, Antoine,Valentin, Alexis,Verhaeghe, Pierre,Wyllie, Susan. "New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi". supporting information. p. 464 - 472. Retrieved 2020/04/30.
• 2、 -. "INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE". Page/Page column 334. . Retrieved 2017/09/02.