20691-92-3

Basic information

• Product Name: 1-METHYL-PIPERIDINE-4-CARBONITRILE
• Synonyms: 1-METHYL-PIPERIDINE-4-CARBONITRILE;1-Methyl-piperidine-4-carbonitrile ,97%;4-Cyano-1-methyl-piperidine;1-Methyl-4-cyanopiperidine;1-Methyl-4-piperidinecarbonitrile;1-Methylisonipecotonitrile
• CAS NO: 20691-92-3
• Molecular Formula: C₇H₁₂N₂
• Molecular Weight: 124.18
• Mol File: 20691-92-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 85-88℃ (14 Torr)
• Flash Point: 79.381 °C
• Appearance: /
• Density: 0.98 g/cm³
• Vapor Pressure: 0.19mmHg at 25°C
• Refractive Index: 1.4615 (20℃)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-METHYL-PIPERIDINE-4-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-PIPERIDINE-4-CARBONITRILE(20691-92-3)
• EPA Substance Registry System: 1-METHYL-PIPERIDINE-4-CARBONITRILE(20691-92-3)

Safety Data

• Statements: 23/24/25-33
• Safety Statements: 28-37-45
• RIDADR: 3276
• Hazardous Substances Data: 20691-92-3(Hazardous Substances Data)

Usage

Chemical Properties

Colourless liquid

InChI:InChI=1/C7H12N2/c1-9-4-2-7(6-8)3-5-9/h7H,2-5H2,1H3

Upstream product

• 62718-28-9 1-methylpiperidine-4-carboxamide 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 1690-75-1 1-methyl-piperidine-4-carboxylic acid methyl ester 
• 4395-98-6 4-cyanopiperidine 
• 50-00-0 formaldehyd 
• 7630-02-6 4-(methoxycarbonyl)-1-methylpyridinium iodide 
• 1453-82-3 isonicotinamide 
• 39546-32-2 4-carboxamidopiperidine 

Downstream Products

• 1027041-17-3 4-[2-(1,4-dimethyl-piperidin-4-yl)-thiazol-4-yl]-benzoic acid 
• 26458-78-6 4-cyanoquinuclidine 
• 78815-71-1 4-benzyl-4-ethoxycarbonyl-1-methylpiperidine 
• 65345-83-7 4-cyano-1-methyl-quinuclidinium; iodide 
• 55022-88-3 1-azabicyclo[2.2.2]octane-4-carboxylic acid 

Relevant articles and documents

Protein Modification at Tyrosine with Iminoxyl Radicals

Post-translational modifications (PTMs) of proteins are a biological mechanism for reversibly controlling protein function. Synthetic protein modifications (SPMs) at specific canonical amino acids can mimic PTMs. However, reversible SPMs at hydrophobic amino acid residues in proteins are especially limited. Here, we report a tyrosine (Tyr)-selective SPM utilizing persistent iminoxyl radicals, which are readily generated from sterically hindered oximes via single-electron oxidation. The reactivity of iminoxyl radicals with Tyr was dependent on the steric and electronic demands of oximes; isopropyl methyl piperidinium oxime 1f formed stable adducts, whereas the reaction of tert-butyl methyl piperidinium oxime 1o was reversible. The difference in reversibility between 1f and 1o, differentiated only by one methyl group, is due to the stability of iminoxyl radicals, which is partly dictated by the bond dissociation energy of oxime O-H groups. The Tyr-selective modifications with 1f and 1o proceeded under physiologically relevant, mild conditions. Specifically, the stable Tyr-modification with 1f introduced functional small molecules, including an azobenzene photoswitch, to proteins. Moreover, masking critical Tyr residues by SPM with 1o, and subsequent deconjugation triggered by the treatment with a thiol, enabled on-demand control of protein functions. We applied this reversible Tyr modification with 1o to alter an enzymatic activity and the binding affinity of a monoclonal antibody with an antigen upon modification/deconjugation. The on-demand ON/OFF switch of protein functions through Tyr-selective and reversible covalent-bond formation will provide unique opportunities in biological research and therapeutics.

5-HT3 receptor agonist, novel thiazole derivative and intermediate thereof

A 5-HT3 receptor against containing a thiazole derivative as the effective ingredient is provided and is represented by the Formula (I): STR1 wherein the A ring is substituted or unsubstituted and represents a benzene or a heterocyclic ring with one or two heteroatoms; one of L1 or L2 represents a single bond and the other is non-existent or represents an alkylene or alkenylene group; R represents: STR2