2-Methoxyquinoxaline

Base Information

• Chemical Name: 2-Methoxyquinoxaline
• CAS No.: 39209-88-6
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.175
• Hs Code.: 2933990090
• NSC Number: 521694
• DSSTox Substance ID: DTXSID00303427
• Nikkaji Number: J406.384H
• Wikidata: Q82048708
• Mol file: 39209-88-6.mol

Synonyms:2-methoxyquinoxaline;39209-88-6;NSC521694;SCHEMBL4526835;DTXSID00303427;NSC-521694;FT-0759606

Chemical Property of 2-Methoxyquinoxaline

Chemical Property:

• Vapor Pressure: 0.0234mmHg at 25°C
• Melting Point: 31-33 °C
• Boiling Point: 257.4°Cat760mmHg
• PKA: 0.55±0.28(Predicted)
• Flash Point: 89.5°C
• PSA: 35.01000
• Density: 1.195g/cm³
• LogP: 1.63840
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 160.063662883
• Heavy Atom Count: 12
• Complexity: 152

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=NC2=CC=CC=C2N=C1

Technology Process of 2-Methoxyquinoxaline

There total 2 articles about 2-Methoxyquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2-chloroquinoxaline (1448-87-9) → 2-methoxy-quinoxaline (39209-88-6) + 2-hydroxyquinoxaline (1196-57-2,144499-26-3)

Guidance literature:

With water; at 40 ℃; Further Variations:; Temperatures; various ratio of mixture methanol-water; Kinetics;

DOI:10.1002/kin.550260403

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-hydroxyquinoxaline (1196-57-2,144499-26-3) → 2-methoxy-quinoxaline (39209-88-6) + 1-methyl-2(1H)-quinoxalinone (6479-18-1)

Guidance literature:

DOI:10.1021/tx960049b

Reference yield: 62.0%

2-methoxy-quinoxaline (39209-88-6) + chloromethyl phenyl sulfone (7205-98-3) → 2-quinoxaline (129919-53-5) + 1,1a-dihydro-1-(phenylsulfonyl)azirino<1.2-a>quinoxalin-2(3H)one (129919-50-2) + 2--1,1a,2,3-tetrahydro-1-(phenylsulfonyl)azirino<1.2-a>quinoxaline (129919-54-6)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; Yields of byproduct given; Ambient temperature;

upstream raw materials:

methanol

2-chloroquinoxaline

diazomethane

2-hydroxyquinoxaline

Downstream raw materials:

2-quinoxaline

1,1a-dihydro-1-(phenylsulfonyl)azirino<1.2-a>quinoxalin-2(3H)one

2--1,1a,2,3-tetrahydro-1-(phenylsulfonyl)azirino<1.2-a>quinoxaline

2-(methylthio)quinoxaline

Refernces

• 1、 Patel. "Kinetics of solvolysis of 2-chloroquinoxaline". . p. 403 - 406. Retrieved 2007/10/03.