ethyl hydroxy[4-(propan-2-yl)phenyl]acetate

Base Information

• Chemical Name: ethyl hydroxy[4-(propan-2-yl)phenyl]acetate
• CAS No.: 6283-47-2
• Molecular Formula: C13H18 O3
• Molecular Weight: 222.284
• Mol file: 6283-47-2.mol

Synonyms:p-Cymene-7-carboxylicacid, 7-hydroxy-, ethyl ester (6CI,8CI); NSC 7499

Chemical Property of ethyl hydroxy[4-(propan-2-yl)phenyl]acetate

Chemical Property:

• Vapor Pressure: 0.000115mmHg at 25°C
• Boiling Point: 322.4°Cat760mmHg
• Flash Point: 129.4°C
• Density: 1.073g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl hydroxy[4-(propan-2-yl)phenyl]acetate

There total 4 articles about ethyl hydroxy[4-(propan-2-yl)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 2-(4-isopropylphenyl)-2-oxoacetate (34906-84-8) → ethyl hydroxy(4-isopropylphenyl)acetate (6283-47-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00137a002

Reference yield: 80.0%

glyoxylic acid ethyl ester (924-44-7) + Isopropylbenzene (98-82-8) → ethyl hydroxy(4-isopropylphenyl)acetate (6283-47-2)

Guidance literature:

With tin(IV) chloride; In dichloromethane; at 20 ℃; for 2h; regioselective reaction;

DOI:10.1055/s-0028-1083154

Reference yield:

Isopropylbenzene (98-82-8) → ethyl hydroxy(4-isopropylphenyl)acetate (6283-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / AlCl₃ / nitrobenzene

2: 94 percent / H₂ / 10percent Pd/C / ethanol

With aluminium trichloride; hydrogen; palladium on activated charcoal; In ethanol; nitrobenzene;

DOI:10.1021/jm00137a002

upstream raw materials:

ethyl 2-(4-isopropylphenyl)-2-oxoacetate

Isopropylbenzene

glyoxylic acid ethyl ester

Downstream raw materials:

2-amino-5-(4-isopropyl-phenyl)-oxazol-4-one

Brom-(4-isopropyl-phenyl)-essigsaeure-ethylester

Fluoro-(4-isopropyl-phenyl)-acetic acid ethyl ester

1-(p-Cumyl)-3-azabicyclo<3.1.0>hexan