(S)-[1-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluorobenzoyl)pyridin-3-yl]pyrrolidin-1-yl}-2-oxoethylcarbamoyl)ethyl]methylcarbamic acid tert-butyl ester

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Chemical Name:(S)-[1-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluorobenzoyl)pyridin-3-yl]pyrrolidin-1-yl}-2-oxoethylcarbamoyl)ethyl]methylcarbamic acid tert-butyl ester
CAS No.:1005342-88-0
Molecular Formula:C₃₃H₄₃FN₄O₅
Molecular Weight:594.727
Hs Code.:

Synonyms:(S)-[1-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluorobenzoyl)pyridin-3-yl]pyrrolidin-1-yl}-2-oxoethylcarbamoyl)ethyl]methylcarbamic acid tert-butyl ester

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Chemical Property of (S)-[1-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluorobenzoyl)pyridin-3-yl]pyrrolidin-1-yl}-2-oxoethylcarbamoyl)ethyl]methylcarbamic acid tert-butyl ester

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Technology Process of (S)-[1-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluorobenzoyl)pyridin-3-yl]pyrrolidin-1-yl}-2-oxoethylcarbamoyl)ethyl]methylcarbamic acid tert-butyl ester

There total 9 articles about (S)-[1-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluorobenzoyl)pyridin-3-yl]pyrrolidin-1-yl}-2-oxoethylcarbamoyl)ethyl]methylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 894789-27-6
(2S)-2-[(2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]propanamido]-2-cyclohexylacetic acid

: 1005342-87-9
(4-fluoro-phenyl)-((S)-5-pyrrolidin-2-yl-pyridin-3-yl)-methanone

: 1005342-88-0
(S)-[1-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluorobenzoyl)pyridin-3-yl]pyrrolidin-1-yl}-2-oxoethylcarbamoyl)ethyl]methylcarbamic acid tert-butyl ester

Guidance literature:: With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield: 77.0%

: 894789-27-6
(2S)-2-[(2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]propanamido]-2-cyclohexylacetic acid

: 1005342-87-9
(4-fluoro-phenyl)-((S)-5-pyrrolidin-2-yl-pyridin-3-yl)-methanone

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: C₂₁H₂₀FN₅O₃

: C₃₃H₄₃FN₄O₅

: 1005342-88-0
(S)-[1-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluorobenzoyl)pyridin-3-yl]pyrrolidin-1-yl}-2-oxoethylcarbamoyl)ethyl]methylcarbamic acid tert-butyl ester

Guidance literature:: In ethyl acetate; at -20 - 20 ℃;
DOI:10.1016/j.tetlet.2008.06.119

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1005342-88-0
(S)-[1-((S)-1-cyclohexyl-2-{(S)-2-[5-(4-fluorobenzoyl)pyridin-3-yl]pyrrolidin-1-yl}-2-oxoethylcarbamoyl)ethyl]methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; diethyl ether / 1 h / -70 - -65 °C

1.2: 2 h / -70 °C

2.1: Dess-Martin periodane / dichloromethane / 0.33 h / 25 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 3 h / -70 - 20 °C

4.1: n-butyllithium / hexane; diethyl ether / -73 - -70 °C

4.2: -73 - -70 °C

5.1: trifluoroacetic acid / 0.5 h / 100 °C / Microwave irradiation

6.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 2 h / 0 - 20 °C

With n-butyllithium; sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;