6-Methoxy-2-methyl-3-nitropyridine

Base Information

• Chemical Name: 6-Methoxy-2-methyl-3-nitropyridine
• CAS No.: 5467-69-6
• Molecular Formula: C7H8N2O3
• Molecular Weight: 168.152
• Hs Code.: 2933399090
• NSC Number: 25401
• DSSTox Substance ID: DTXSID90282313
• Wikidata: Q72517338
• Mol file: 5467-69-6.mol

Synonyms:6-Methoxy-2-methyl-3-nitropyridine;5467-69-6;6-Methoxy-3-nitro-2-picoline;2-METHOXY-5-NITRO-6-PICOLINE;MFCD03095076;Pyridine, 6-methoxy-2-methyl-3-nitro-;2-Methoxy-6-Methyl-5-Nitropyridine;6-methoxy-2-methyl-3-nitro-pyridine;NSC25401;6-Methoxy-3-nitro-2-methylpyridine;SCHEMBL1428159;DTXSID90282313;2-Methoxy-5-Nitro-6-Methylpyridine;NSC-25401;AKOS006278868;6-Methoxy-2-methyl-3-nitropyridine #;AM62475;AC-31263;AS-14961;SY031481;A7936;CS-0082350;FT-0646316;EN300-104001;Z1198161540;InChI=1/C7H8N2O3/c1-5-6(9(10)11)3-4-7(8-5)12-2/h3-4H,1-2H

Chemical Property of 6-Methoxy-2-methyl-3-nitropyridine

Chemical Property:

• Vapor Pressure: 3.73E-16mmHg at 25°C
• Melting Point: 104-108 °C
• Refractive Index: 1.84
• Boiling Point: 261.1 °C at 760 mmHg
• PKA: 0.09±0.10(Predicted)
• Flash Point: 111.7 °C
• PSA: 67.94000
• Density: 1.247 g/cm³
• LogP: 1.83000
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 168.05349212
• Heavy Atom Count: 12
• Complexity: 169

Purity/Quality:

99% ^*data from raw suppliers

1-Ethyl-6-methyl-5-nitropyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=N1)OC)[N+](=O)[O-]

Technology Process of 6-Methoxy-2-methyl-3-nitropyridine

There total 11 articles about 6-Methoxy-2-methyl-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 6-chloro-4-methyl-3-nitropyridine (22280-60-0) → 6-methoxy-3-nitro-2-picoline (5467-69-6)

Guidance literature:

methanol; 6-chloro-4-methyl-3-nitropyridine; With sodium; at 0 ℃; for 4h;

With acetic acid;

Reference yield: 86.0%

2-methoxy-6-methyl-pyridine (63071-03-4) → 6-methoxy-3-nitro-2-picoline (5467-69-6)

Guidance literature:

With sulfuric acid; nitric acid; In water; at 20 - 80 ℃;

Reference yield: 54.0%

2-methoxy-5-nitropyridine (5446-92-4) + methanesulfonic acid 2,2-dimethyl-propyl ester (16427-42-2) → 6-methoxy-3-nitro-2-picoline (5467-69-6)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at -40 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03920

upstream raw materials:

6-chloro-4-methyl-3-nitropyridine

sodium methylate

methanol

6-methyl-5-nitropyridin-2-ol

Downstream raw materials:

6-methyl-5-nitropyridin-2-ol

5-methoxy-4-aza-1H-indole

2,6-Dibrom-1,5-naphthyridin

5-methoxy-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid

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