Synonyms:Potassiumhydride (8CI); Potassium monohydride
98%min *data from raw suppliers
Potassium hydride, 30-35% in oil *data from reagent suppliers
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There total 1 articles about Potassium hydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
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The research focuses on the stereoselective formation of glucal epoxides, which are crucial intermediates in the synthesis of oligosaccharides and other carbohydrate derivatives. The study aimed to find an alternative approach to the existing method of dimethyldioxirane (DMD) oxidation, which has limitations such as the need for rigorous drying and difficulty in scaling up. The researchers explored the cyclization of bromohydrins as a route to glucal epoxide formation, using chemicals such as N-bromoacetamide (NBA), sodium hydride (NaH), potassium hydride (KH), 18-crown-6, sodium phenylthiolate, sodium azide, methoxide, and benzyloxide. They observed that the reaction conditions significantly affected the diastereoselectivity of the epoxide formation, leading to different ratios of a-manno and β-gluco products. The study concluded that the formation and cyclization of bromohydrins offer an alternative route for glucal epoxide synthesis, with potential applications to other carbohydrate substrates, and highlighted the importance of metal ions and solvents in modifying the relative reactivities of the anomeric alkoxides, which influence the stereoselectivity of the cyclization process.
The study presents a novel method for the intermolecular R-arylation and vinylation of amides through palladium-catalyzed coupling of aryl and vinyl bromides with zinc enolates of amides. The researchers developed reactions using three different types of zinc enolates, achieving high yields with a variety of bromoarenes, including those with functional groups such as cyano, nitro, ester, keto, fluoro, hydroxyl, or amino. The use of zinc enolates, as opposed to alkali metal enolates, significantly expands the scope of amide arylation by allowing reactions at room temperature or 70 °C and by tolerating a broader range of functional groups. The study also introduces the use of morpholine amides, which are precursors to ketones and aldehydes, in the arylation process. The reactions were facilitated by catalysts bearing hindered pentaphenylferrocenyl di-tert-butylphosphine (Q-phos) or the highly reactive, dimeric Pd(I) complex {[P(t-Bu)3]PdBr}2, offering a mild and efficient approach to synthesize R-aryl carbonyl compounds, which are prevalent in pharmaceuticals and biologically active compounds.
The study presents an optimized method for methylation analysis of oligo- and polysaccharides. The authors examined and refined each step of the procedure to enhance quantitative recovery and speed. Key chemicals involved include potassium methylsulphinyl carbanion, generated from potassium hydride, which is used to form polyalkoxide ions necessary for methylation. Methyl iodide is employed for the methylation of these ions. Other reagents such as trifluoroacetic acid for hydrolysis, sodium borohydride for reduction, and acetic anhydride for acetylation are used in subsequent steps to convert the methylated carbohydrates into analyzable derivatives. The study also utilizes 2,2-dimethoxypropane to remove residual water after washing steps, ensuring efficient evaporation and isolation of the methylated products. The improved procedure allows for complete methylation, high recoveries of acetylated alditols of methylated sugars, and the analysis to be completed within a working day, making it a convenient and efficient method for determining glycosyl linkages in a wide range of oligo- and polysaccharides.
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