BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL

Base Information

• Chemical Name: BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL
• CAS No.: 733-83-5
• Molecular Formula: C14H9F5O
• Molecular Weight: 288.21
• Hs Code.: 2906299090
• Mol file: 733-83-5.mol

Synonyms:Benzhydrol,4,4'-difluoro-a-(trifluoromethyl)-(6CI,8CI);NSC 88625;

Chemical Property of BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL

Chemical Property:

• Vapor Pressure: 9.97E-05mmHg at 25°C
• Refractive Index: 1.504
• Boiling Point: 324.6 °C at 760 mmHg
• Flash Point: 150.1 °C
• PSA: 20.23000
• Density: 1.382 g/cm³
• LogP: 3.76300

Purity/Quality:

98%min ^*data from raw suppliers

Bis(4-fluorophenyl)trifluoromethyl carbinol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL

There total 4 articles about BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4,4'-Difluorobenzophenone (345-92-6) + 1-(4-benzylpiperazin-1-yl)-2, 2, 2-trifluoroethanol (345959-36-6) → 2,2,2-trifluoro-1,1-bis(4-fluorophenyl)ethanol (733-83-5)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 25 ℃; for 24h;

DOI:10.1002/1099-0690(200104)2001:8<1467::AID-EJOC1467>3.0.CO;2-A

Reference yield:

trifluoromethan (75-46-7) + tris(trimethylsilyl)amine (1586-73-8) + 4,4'-Difluorobenzophenone (345-92-6) → 2,2,2-trifluoro-1,1-bis(4-fluorophenyl)ethanol (733-83-5) + trimethyl-[2,2,2-trifluoro-1,1-bis-(4-fluoro-phenyl)-ethoxy]-silane

Guidance literature:

cesium fluoride; In N,N-dimethyl-formamide; at -10 - 20 ℃; for 6h;

DOI:10.1021/jo000150s

Reference yield:

ethyl trifluoroacetate, (383-63-1) + 4-flourophenylmagnesium bromide (352-13-6) → 2,2,2-trifluoro-1,1-bis(4-fluorophenyl)ethanol (733-83-5)

Guidance literature:

With diethyl ether;

DOI:10.1021/ja01620a064

upstream raw materials:

ethyl trifluoroacetate,

4-flourophenylmagnesium bromide

trifluoroacetic anhydride

trifluoromethan

Downstream raw materials:

toluene-4-sulfonic acid 2,2,2-trifluoro-1,1-bis-(4-fluoro-phenyl)-ethyl ester

ethyl 2,2-bis(4-fluorophenyl)acetate

2,2-bis(4-fluorophenyl)acetic acid

N-<1,1-Bis-(4-fluor-phenyl)-2,2,2-trifluor-aethyl>-acetamid

Refernces

• 1、 Large,Roques,Langlois. "Nucleophilic trifluoromethylation of carbonyl compounds and disulfides with trifluoromethane and silicon-containing bases". . p. 8848 - 8856. Retrieved 2007/10/03.