4-(3-Phenylpropyl)pyridine

Base Information

• Chemical Name: 4-(3-Phenylpropyl)pyridine
• CAS No.: 2057-49-0
• Molecular Formula: C14H15N
• Molecular Weight: 197.28
• Hs Code.: 29333999
• European Community (EC) Number: 218-159-1
• UNII: YW9Q68EK6B
• DSSTox Substance ID: DTXSID5044869
• Nikkaji Number: J151.168H
• Wikidata: Q26840907
• ChEMBL ID: CHEMBL3186973
• Mol file: 2057-49-0.mol

Synonyms:(4-(3-phenylpropyl)pyridine);4-(3-phenylpropyl)pyridine

Chemical Property of 4-(3-Phenylpropyl)pyridine

Chemical Property:

• Appearance/Colour: colourless to light yellow liquid
• Vapor Pressure: 0.000541mmHg at 25°C
• Refractive Index: n20/D 1.563(lit.)
• Boiling Point: 321.999 °C at 760 mmHg
• PKA: 6.05±0.10(Predicted)
• Flash Point: 131.227 °C
• PSA: 12.89000
• Density: 1.024 g/cm³
• LogP: 3.25690
• Solubility.: Difficult to mix.
• Water Solubility.: 318.5mg/L at 25℃
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 197.120449483
• Heavy Atom Count: 15
• Complexity: 155

Purity/Quality:

99.9% ^*data from raw suppliers

4-(3-Phenylpropyl)pyridine >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCCC2=CC=NC=C2
• Uses: 4-(3-Phenylpropyl)pyridine (CAS# 2057-49-0) is used in preparing various catalytic mediums. It is used in the preparation of a N-heterocyclic carbene ligand for selective C-4 alkylation of pyridine by nickel/Lewis acid catalysts. It is also used in the preparation of (phenylpropyl)pyridine oxide for manganese-salen-catalyzed asymmetric epoxidation of indene. Additionally, it is also used in the regioselective preparation of diaryloxindoles by arylation of isatins with substituted benzenes in superacidic solutions.

Technology Process of 4-(3-Phenylpropyl)pyridine

There total 22 articles about 4-(3-Phenylpropyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(3-phenylpropyl)pyridine-N-oxide (84824-92-0) → 4-(3-phenylpropyl)pyridine (2057-49-0)

Guidance literature:

With methyloxorhenium(V)(2-(mercaptomethyl)thiophenolate) triphenylphosphine; triphenylphosphine; In benzene; at 20 ℃; for 0.3h;

DOI:10.1021/ol006595k

Reference yield: 95.0%

pyridine (110-86-1) + allylbenzene (300-57-2,57807-91-7) → 4-(3-phenylpropyl)pyridine (2057-49-0)

Guidance literature:

allylbenzene; With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; N,N′-bis(2,6-dimethylphenyl)imidazol-2-ylidene; In toluene; for 0.0833333h; Glovebox; Inert atmosphere;

pyridine; With bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum; In toluene; at 130 ℃; for 18h; Reagent/catalyst; Time; regioselective reaction; Sealed tube;

DOI:10.1039/c5cc07455j

Reference yield: 95.0%

4-vinylpyridine (100-43-6,329041-72-7) + benzaldehyde, hydrazone (5281-18-5) → 4-(3-phenylpropyl)pyridine (2057-49-0)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 1,2-bis(dimethylphosphanyl)ethane; lithium tert-butoxide; In tetrahydrofuran; at 80 ℃; for 12h; Reagent/catalyst; regioselective reaction; Inert atmosphere;

DOI:10.1039/d0sc06586b

upstream raw materials:

picoline

styrene

3-Oxo-1-phenyl-3-pyridin-4-ylpropan

1-phenyl-2-bromoethane

Downstream raw materials:

4-(3-phenylpropyl)pyridine-N-oxide

1-methyl-4-(3-phenylpropyl)-1,2,3,6-tetrahydropyridine

Refernces

Ruthenium nanoparticles supported on multi-walled carbon nanotubes: Highly effective catalytic system for hydrogenation processes

10.1016/j.molcata.2010.09.006

The study presents the preparation and evaluation of ruthenium nanoparticles supported on multi-walled carbon nanotubes (RuL-MWCNT) for their catalytic efficiency in hydrogenation reactions. The nanoparticles were synthesized using a ligand stabilization method and characterized by elemental analysis and transmission electronic microscopy. The catalytic performance of the supported RuL-MWCNT was compared with non-supported ruthenium nanoparticles and ruthenium nanoparticles supported on other materials like silica, alumina, and activated carbon. The study found that the RuL-MWCNT catalyst demonstrated superior activity and selectivity in converting various unsaturated substrates to fully hydrogenated products, maintaining its catalytic behavior even after recycling. The support's nature significantly influenced the catalytic activity, with MWCNT showing the best results among the tested supports. The study concludes that the RuL-MWCNT system is an effective catalyst for hydrogenation processes, offering high activity, selectivity, and recyclability.