6282-12-8

Basic information

• Product Name: 2,4-Diacetylaminotoluene
• Synonyms: 2,4-Diacetylaminotoluene;N-(3-acetamido-4-methylphenyl)acetamide
• CAS NO: 6282-12-8
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.24
• Mol File: 6282-12-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-Diacetylaminotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Diacetylaminotoluene(6282-12-8)
• EPA Substance Registry System: 2,4-Diacetylaminotoluene(6282-12-8)

Safety Data

• Hazardous Substances Data: 6282-12-8(Hazardous Substances Data)

Usage

Uses

Used in Dye Production:
2,4-Diacetylaminotoluene is used as a key component in the production of dyes, particularly azo dyes, which are widely used in various industries for coloring textiles, plastics, and other materials. Its chemical properties make it an effective intermediate for dye synthesis.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2,4-Diacetylaminotoluene serves as a precursor for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agricultural Chemical Production:
2,4-Diacetylaminotoluene is also utilized as an intermediate in the synthesis of agricultural chemicals, such as pesticides and herbicides. Its role in these processes contributes to the development of effective solutions for crop protection and management.

Upstream product

• 60-35-5 acetamide 
• 95-80-7 4-methylbenzene-1,3-diamine 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 102276-79-9 4,4'-dimethyl-2,3'-dinitro-ONN-azoxybenzene 

Downstream Products

• 4403-69-4 2-amino-1-benzylamine 
• 1606159-00-5 C₈H₇N₃OS 
• 20828-46-0 N,N'-(4-amino-6-methyl-m-phenylene)-bis-acetamide 
• 780719-70-2 5-methyl-1,2,3,4-benzenetetramine 
• 405911-06-0 2,4-diacetylamino-5-chlorotoluene 
• 25199-25-1 2,4-bis-acetylamino-benzaldehyde 
• 73748-78-4 2,4-diacetylaminobenzoic acid 
• 56850-44-3 4-methyl-2,6-dinitro-m-phenylenediamine 
• 611-03-0 4-amino-2-aminobenzoic acid 

Relevant articles and documents

Co3O4 nanoparticles prepared by oxidative precipitation method: an efficient and reusable heterogeneous catalyst for N-formylation of amines

Abstract: N-formylation of different amines was carried out with formic acid in the presence of the Co3O4 nanoparticles as an efficient, stable heterogeneous catalyst to give the corresponding formamides under solvent-free conditions. This method has advantages over the reported methods such as high yields, mild conditions, easy work-up and short reaction times. The catalyst was characterized by different techniques such as XRD, SEM and FT-IR spectroscopy. Graphical Abstract: [Figure not available: see fulltext.]

Impregnated copper on Fe3O4: an efficient magnetically separable nanocatalyst for rapid and selective acylation of amines

The present paper describes the synthesis of N-arylacetamides through acetylation of arylamines with Ac2O in the presence of magnetically recyclable Fe3O4/Cu NPs. All reactions were carried out efficiently in H2O within 2–10?min to give the products in 89–95% yields. Selective acetylation of amines versus alcohols was carried out successfully with this acetylating system. In addition, acetylation of amines and phenols was taken place with the same reactivity. Reusability of the nanocatalyst was examined 5 times without significant loss of its catalytic activity.

Functionalization of quinazolin-4-ones part 1: Synthesis of novel 7-substituted-2-thioxo quinazolin-4-ones from 4-substituted-2-aminobenzoic acids and PPh3(SCN)2

4-(Nitro, amino, acetylamino)-2-aminobenzoic acid were allowed to react with PPh3(SCN)2 and gave the crossholding 7-nitro, 7-acetylamino- and 7-amino-2-thioxo quinazolin-4-ones respectively. The nature of the substituent at position 4 of the 2-aminobenzoic acids has significant influence on the outcome of the cyclisation reaction with PPh 3(SCN)2. Similarly, the nature of the substituent at position 7 of the 2-substituted quinazolin-4-ones significantly affected the ease with which alkylation reactions could be performed. The alkylation selectivity of the 7- substiuted-2-thioxo quinazolin-4-ones was found to depend on the nature of the alkyl halide and the nature of the substituent at position 2.

NITRO DERIVATIVES OF AROMATIC AZOXY COMPOUNDS. PART I. 2,2'- AND 4,4'-DIMETHYLAZOXYBENZENE NITRATION PRODUCTS

By nitration of 2,2'-dimethylazoxybenzene (1) with concentrated nitric acid under conditions of increasing severity we obtained in succession nitro derivatives having their nitro groups in position: 4; 3',4 and 2,3',4.From 4,4'-dimethylazoxybenzene (2) we obtained similar products with nitro groups in positions: 2,3' (plus 2,6-isomer) and 2,3',6.Trinitro derivatives were obtained also by nitration of dinitro compounds, while tetranitro derivatives: 2,3',4,5' and 2,3',5',6 were obtained by nitrating trinitro compounds (in the presence of phosphoric acid).By reduction with stannous chloride in a strongly acidic medium we obtained, parallel to monocyclic aromatic amines and the conventional benzidine rearrangement products, also 4,4'-dimethyl-2,3'-diaminoazoxybenzene from dinitro derivative 2b, and 3,3'-dimethylbenzidine from mononitro derivative 1a, the latter being quite unexpected.