THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE

Base Information

• Chemical Name: THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE
• CAS No.: 53174-98-4
• Molecular Formula: C8H5NOS
• Molecular Weight: 163.2
• Hs Code.: 2934999090
• Mol file: 53174-98-4.mol

Synonyms:THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE;THIENO[2,3-B]PYRIDINE-2-CARBOXALDEHYDE;Thieno[2,3-b]pyridine-2-carboxaldehyde 97%;Thieno[2,3-b]pyridine-2-carboxaldehyde 97+%;2-Formylthieno[2,3-b]pyridine

Chemical Property of THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 0.000323mmHg at 25°C
• Melting Point: 142 °C
• Refractive Index: 1.735
• Boiling Point: 320.2 °C at 760 mmHg
• PKA: 3.37±0.40(Predicted)
• Flash Point: 147.5 °C
• PSA: 58.20000
• Density: 1.384g/cm³
• LogP: 2.10880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Thieno[2,3-b]pyridine-2-carboxaldehyde 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE

There total 4 articles about THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(hydroxymethyl)thieno<2,3-b>pyridine (131337-81-0) → 2-formylthieno<2,3-b>pyridine (53174-98-4)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃;

Reference yield: 66.0%

thieno[2,3-b]pyridine (272-23-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-formylthieno<2,3-b>pyridine (53174-98-4)

Guidance literature:

thieno[2,3-b]pyridine; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In hexane; at 20 ℃; for 19h; Inert atmosphere; Cooling with ethanol-dry ice;

N,N-dimethyl-formamide; In hexane; for 1h; Cooling with ice; Inert atmosphere;

DOI:10.1016/j.tetlet.2017.04.021

Reference yield:

2-chloro-3-carbaldehydepyridine (36404-88-3) → 2-formylthieno<2,3-b>pyridine (53174-98-4)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 3 h / 100 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C

3: manganese(IV) oxide / dichloromethane / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

thieno[2,3-b]pyridine

N,N-dimethyl-formamide

2-chloro-3-carbaldehydepyridine

methyl thieno[2,3-b]pyridine-2-carboxylate

Downstream raw materials:

thieno[2,3-b]pyridin-2-ylmethanamine

N-((2-(methylsulfanyl)phenyl)(thieno[2,3-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

N-((2-methoxyphenyl)(thieno[2,3-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

N-(phenyl(thieno[2,3-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Refernces

• 1、 -. "SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS". . . Retrieved 2015/05/19.