n,n'-Dimethyl-n'-phenylacetohydrazide

Base Information

• Chemical Name: n,n'-Dimethyl-n'-phenylacetohydrazide
• CAS No.: 42108-38-3
• Molecular Formula: C10H14N2O
• Molecular Weight: 178.234
• NSC Number: 86536
• DSSTox Substance ID: DTXSID10962281
• Nikkaji Number: J828.317F
• Wikidata: Q82943920
• Mol file: 42108-38-3.mol

Synonyms:n,n'-dimethyl-n'-phenylacetohydrazide;42108-38-3;NSC86536;NCIOpen2_001063;DTXSID10962281;NSC-86536;1,2-dimethyl-1-phenyl-2-acetylhydrazine;EN300-195559

Chemical Property of n,n'-Dimethyl-n'-phenylacetohydrazide

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 178.110613074
• Heavy Atom Count: 13
• Complexity: 176

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N(C)N(C)C1=CC=CC=C1

Technology Process of n,n'-Dimethyl-n'-phenylacetohydrazide

There total 7 articles about n,n'-Dimethyl-n'-phenylacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-acetyl-2-phenylhydrazine (114-83-0) + methyl iodide (74-88-4) → N-acetyl-N,N'-dimethyl-N'-phenylhydrazine (42108-38-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1016/j.tetlet.2009.02.060

Reference yield: 80.0%

dimethyl sulfate (77-78-1) + N'-methyl-N'-phenylacetohydrazide (38604-68-1) → N-acetyl-N,N'-dimethyl-N'-phenylhydrazine (42108-38-3)

Guidance literature:

With sodium hydroxide; In benzene; at 20 - 25 ℃; for 6h;

Reference yield: 16.0%

dimethyl sulfate (77-78-1) + 1-acetyl-2-phenylhydrazine (114-83-0) → N-acetyl-N,N'-dimethyl-N'-phenylhydrazine (42108-38-3) + 1-acetyl-1-methyl-2-phenylhydrazine (38604-70-5) + N'-methyl-N'-phenylacetohydrazide (38604-68-1)

Guidance literature:

With sodium hydroxide; In benzene;

upstream raw materials:

N'-methyl-N'-phenylacetohydrazide

dimethyl sulfate

1-acetyl-2-phenylhydrazine

1-Methyl-1-phenylhydrazine

Downstream raw materials:

N-ethyl-N,N'-dimethyl-N'-phenyl-hydrazine

1,2-dimethylindole