2-Methyl-2-thiazoline

Base Information

• Chemical Name: 2-Methyl-2-thiazoline
• CAS No.: 2346-00-1
• Molecular Formula: C4H7NS
• Molecular Weight: 101.172
• Hs Code.: 29341000
• European Community (EC) Number: 219-071-6
• UNII: 8Z6UA8V7WN
• DSSTox Substance ID: DTXSID1062336
• Nikkaji Number: J37.314A
• Wikidata: Q27271229
• Metabolomics Workbench ID: 43900
• Mol file: 2346-00-1.mol

Synonyms:2-methyl-2-thiazoline;2-methylthiazoline

Chemical Property of 2-Methyl-2-thiazoline

Chemical Property:

• Appearance/Colour: colorless to orange-yellow liquid
• Vapor Pressure: 6.25mmHg at 25°C
• Melting Point: -101.0 °C(lit.)
• Refractive Index: n20/D 1.520(lit.)
• Boiling Point: 144.999 °C at 760 mmHg
• PKA: 5.26±0.10(Predicted)
• Flash Point: 37.222 °C
• PSA: 37.66000
• Density: 1.175 g/cm³
• LogP: 0.58720
• Storage Temp.: 2-8°C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 101.02992040
• Heavy Atom Count: 6
• Complexity: 77.6

Purity/Quality:

99% ^*data from raw suppliers

2-Methylthiazoline >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R10:
• Hazard Codes: R10:
• Statements: 10
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NCCS1
• Uses: Meyers reagent for aldehyde synthesis.

Technology Process of 2-Methyl-2-thiazoline

There total 16 articles about 2-Methyl-2-thiazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

acetyl chloride (75-36-5) → 2-methyl-4,5-dihydro-thiazole (2346-00-1)

Guidance literature:

acetyl chloride; ethanolamine; With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

With Lawessons reagent; In toluene; for 0.25h; Further stages.; Heating;

DOI:10.1016/j.tetlet.2004.09.182

Reference yield: 60.0%

2-acetylaminoethanol (142-26-7) → 2-methyl-4,5-dihydro-thiazole (2346-00-1)

Guidance literature:

With tetraphosphorus decasulfide; at 120 - 130 ℃; for 1.5h; suspension in mineral acid;

Reference yield: 40.0%

2-methylthiazolidine (24050-16-6) → 2-methyl-4,5-dihydro-thiazole (2346-00-1)

Guidance literature:

With tert.-butylhydroperoxide; ruthenium(II) bis(triphenylphosphine) dichloride; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/S0040-4039(00)00419-6

upstream raw materials:

2-(acetylamino)ethanethiol

2-acetylaminoethanol

ethanolamine

thioacetamide

Downstream raw materials:

(4,5-dihydro-thiazol-2-yl)-acetone

(E)-2-[2-phenylethenyl]-4,5-dihydro-1,3-thiazole

2-[trans-2-(4,5-dihydro-thiazol-2-yl)-vinyl]-phenol

2-methyl-3-ethyl-4,5-dihydrothiazolium iodide