N-Formyl-1-aminopyrene

Base Information

• Chemical Name: N-Formyl-1-aminopyrene
• CAS No.: 103915-43-1
• Molecular Formula: C17H11 N O
• Molecular Weight: 245.28
• UNII: 0QG4IU067Z
• DSSTox Substance ID: DTXSID30146142
• Nikkaji Number: J792.795I
• Wikidata: Q27237106
• Mol file: 103915-43-1.mol

Synonyms:N-formyl-1-aminopyrene;NFAP

Chemical Property of N-Formyl-1-aminopyrene

Chemical Property:

• Vapor Pressure: 1.18E-10mmHg at 25°C
• Boiling Point: 513.4°Cat760mmHg
• Flash Point: 306.3°C
• PSA: 32.59000
• Density: 1.372g/cm³
• LogP: 4.80180
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 245.084063974
• Heavy Atom Count: 19
• Complexity: 355

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)NC=O

Technology Process of N-Formyl-1-aminopyrene

There total 2 articles about N-Formyl-1-aminopyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

formic acid (64-18-6) + 1-aminopyrene (1606-67-3) → 1-Formylaminopyrene (103915-43-1)

Guidance literature:

for 12h; Reflux; Inert atmosphere; Schlenk technique;

DOI:10.1002/asia.201900798

Reference yield:

1-bromopyrene (1714-29-0) + formamide (77287-34-4,77287-35-5,60100-09-6) → 1-Formylaminopyrene (103915-43-1)

Guidance literature:

With copper(ll) sulfate pentahydrate; potassium carbonate; at 160 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02037

Reference yield:

1-Formylaminopyrene (103915-43-1) → 1-aminopyrene (1606-67-3)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 1h; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.9b02037

upstream raw materials:

formic acid

1-aminopyrene

1-bromopyrene

formamide

Downstream raw materials:

1-amino-6-nitropyrene

1-aminopyrene

Refernces

• 1、 Ying, Jun,Fu, Lu-Yang,Zhong, Guoqiang,Wu, Xiao-Feng. "Cobalt-Catalyzed Direct Carbonylative Synthesis of Free (NH)-Benzo[ cd]indol-2(1 H)-ones from Naphthylamides". supporting information. p. 5694 - 5698. Retrieved 2019/07/08.