Acetic acid, [(4-chlorophenyl)sulfinyl]-, methyl ester, (R)-

Base Information

• Chemical Name: Acetic acid, [(4-chlorophenyl)sulfinyl]-, methyl ester, (R)-
• CAS No.: 102340-69-2
• Molecular Formula: C9H9ClO3S
• Molecular Weight: 232.688
• Mol file: 102340-69-2.mol

Synonyms:

Chemical Property of Acetic acid, [(4-chlorophenyl)sulfinyl]-, methyl ester, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid, [(4-chlorophenyl)sulfinyl]-, methyl ester, (R)-

There total 9 articles about Acetic acid, [(4-chlorophenyl)sulfinyl]-, methyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(+/-)-Methyl (cyclohexylsulfinyl)acetate (125706-40-3) → (R)-(+)-Methyl <(4-chlorophenyl)sulfinyl>acetate (102340-69-2) + (S)-(-)-<(4-Chlorophenyl)sulfinyl>acetic acid (125706-42-5)

Guidance literature:

With water; In toluene; at 25 ℃; for 96h; Yield given; Pseudomonas sp. K-10, 0.05M phosphate buffer (pH=7.5);

DOI:10.1016/S0040-4039(01)80467-6

Reference yield: 48.0%

methyl 4-chlorophenylsulfinylacetate (73281-90-0) → (R)-(+)-Methyl <(4-chlorophenyl)sulfinyl>acetate (102340-69-2) + <(4-Chlorophenyl)sulfinyl>acetic acid (69529-90-4) + (S)-(-)-<(4-Chlorophenyl)sulfinyl>acetic acid (125706-42-5)

Guidance literature:

With water; In toluene; at 25 ℃; for 25h; Yields of byproduct given; Pseudomonas sp. K-10, 0.05M phosphate buffer (pH=7.5);

DOI:10.1016/S0040-4039(01)80467-6

Reference yield: 30.0%

methyl 4-chlorophenylsulfinylacetate (73281-90-0) → (R)-(+)-Methyl <(4-chlorophenyl)sulfinyl>acetate (102340-69-2)

Guidance literature:

at 30 ℃;

DOI:10.1246/cl.1986.217

upstream raw materials:

methyl 4-chlorophenylsulfinylacetate

(+/-)-Methyl (cyclohexylsulfinyl)acetate

(R)-1-chloro-4-(methylsulfinyl)benzene

carbonic acid dimethyl ester

Downstream raw materials:

(S),(E)-Methyl 5-cyclohexyl-4-hydroxypent-2-enoate

(R),(E)-Methyl 5-cyclohexyl-4-hydroxypent-2-enoate

methyl 4-hydroxy-4-phenyl-(E)-but-2-enoate

Refernces

• 1、 Trost,Mallart. "Double diastereodifferentiation in the hydroxylative Knovenagel condensation". . p. 8025 - 8028. Retrieved 2007/10/02.
• 2、 Ohta, Hiromichi,Kato, Yasuo,Tsuchihashi, Gen-ichi. "ENZYME MEDIATED SYNTHESIS OF OPTOCALLY ACTIVE ο-ARENESULFINYLALKANOIC ESTERS". . p. 217 - 218. Retrieved 2007/10/02.