2-Pyridinecarboxamide, N-cyclohexyl-

Base Information

• Chemical Name: 2-Pyridinecarboxamide, N-cyclohexyl-
• CAS No.: 10354-50-4
• Molecular Formula: C12H16N2O
• Molecular Weight: 204.272
• DSSTox Substance ID: DTXSID20442408
• Nikkaji Number: J1.203.760K
• Wikidata: Q82259665
• Mol file: 10354-50-4.mol

Synonyms:N-cyclohexylpyridine-2-carboxamide;2-Pyridinecarboxamide, N-cyclohexyl-;10354-50-4;N-Cyclohexylpicolinamide;SCHEMBL2590689;DTXSID20442408;AKOS001368479;Z31484164

Chemical Property of 2-Pyridinecarboxamide, N-cyclohexyl-

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 204.126263138
• Heavy Atom Count: 15
• Complexity: 212

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC(CC1)NC(=O)C2=CC=CC=N2

Technology Process of 2-Pyridinecarboxamide, N-cyclohexyl-

There total 10 articles about 2-Pyridinecarboxamide, N-cyclohexyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Picolinic acid (98-98-6) + cyclohexylamine (108-91-8,157973-60-9) → N-picolinoylcyclohexylamine (10354-50-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1002/anie.202106716

Reference yield: 84.0%

pyridine-2-carboxylic acid amide (1452-77-3) + cyclohexane (110-82-7,25012-93-5) → N-picolinoylcyclohexylamine (10354-50-4)

Guidance literature:

With copper(l) iodide; di-tert-butyl peroxide; 4,7-dimethoxy-1,10-phenanthroline; In benzene; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja411912p

Reference yield: 73.0%

pyridine (110-86-1) + Cyclohexyl isocyanide (931-53-3) → 2-(1-cyclohexyl-1H-tetrazol-5-yl)pyridine + tetrazolo[1,5-a]pyridine (274-87-3) + N-picolinoylcyclohexylamine (10354-50-4)

Guidance literature:

pyridine; With fluorine; In chloroform; at -78 - -60 ℃;

Cyclohexyl isocyanide; With trimethylsilylazide; In chloroform; at -50 - 0 ℃;

DOI:10.1016/j.tetlet.2005.05.066

upstream raw materials:

pyridine

Cyclohexyl isocyanide

2-Picolinic acid

cyclohexylamine