4-hydroxy-N,N-dimethylbenzamide

Base Information

• Chemical Name: 4-hydroxy-N,N-dimethylbenzamide
• CAS No.: 20876-99-7
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• Mol file: 20876-99-7.mol

Synonyms:4-hydroxy N,N-dimethylbenzamide;N,N-dimethyl-4-hydroxybenzamide;Benzamide, 4-hydroxy-N,N-dimethyl-;4-Hydroxy-benzoesaeure-dimethylamid;4-hydroxy-benzoic acid dimethyl amide;

Chemical Property of 4-hydroxy-N,N-dimethylbenzamide

Chemical Property:

• Vapor Pressure: 3.74E-05mmHg at 25°C
• Melting Point: 161-162 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 342.6°C at 760 mmHg
• PKA: 8.41±0.13(Predicted)
• Flash Point: 161°C
• PSA: 40.54000
• Density: 1.153g/cm³
• LogP: 1.09400

Purity/Quality:

97% ^*data from raw suppliers

4-hydroxy-N,N-dimethylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydroxy-N,N-dimethylbenzamide

There total 13 articles about 4-hydroxy-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

p-Iodophenol (540-38-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-hydroxy-N,N-dimethyl-benzamide (20876-99-7)

Guidance literature:

With palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; at 135 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jo200754v

Reference yield: 87.0%

4-(benzyloxy)-N,N-dimethylbenzamide (84403-55-4) → 4-hydroxy-N,N-dimethyl-benzamide (20876-99-7)

Guidance literature:

With potassium tert-butylate; diphenylphosphane; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Sealed tube;

DOI:10.1039/d1ob01286j

Reference yield: 85.0%

N,N-dimethyl-4-methoxybenzamide (7291-00-1) → 4-hydroxy-N,N-dimethyl-benzamide (20876-99-7)

Guidance literature:

With potassium tert-butylate; diphenylphosphane; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Sealed tube;

DOI:10.1039/d1ob01286j

upstream raw materials:

N,N-dimethyl-formamide

4-hydroxy-benzoic acid

4-bromo-phenol

p-Iodophenol

Downstream raw materials:

Isopropoxymethyl-phosphonothioic acid O-(4-dimethylcarbamoyl-phenyl) ester O-ethyl ester

4-(3-Chloro-propoxy)-N,N-dimethyl-benzamide

N,N-dimethyl-4-fluorobenzamide

C₁₉H₁₇ClN₄O₂S