4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-N,N-dimethyl-benzamide; compound with (E)-but-2-enedioic acid

Base Information

• Chemical Name: 4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-N,N-dimethyl-benzamide; compound with (E)-but-2-enedioic acid
• CAS No.: 117023-73-1
• Molecular Formula: C₄H₄O₄*C₃₀H₃₄F₂N₂O₃
• Molecular Weight: 624.682
• Mol file: 117023-73-1.mol

Synonyms:4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-N,N-dimethyl-benzamide; compound with (E)-but-2-enedioic acid

Chemical Property of 4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-N,N-dimethyl-benzamide; compound with (E)-but-2-enedioic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-N,N-dimethyl-benzamide; compound with (E)-but-2-enedioic acid

There total 5 articles about 4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-N,N-dimethyl-benzamide; compound with (E)-but-2-enedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol (60284-98-2) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) + 4-(3-Chloro-propoxy)-N,N-dimethyl-benzamide (117022-51-2) → 4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-N,N-dimethyl-benzamide; compound with (E)-but-2-enedioic acid (117023-73-1)

Guidance literature:

With sodium carbonate; potassium iodide; 1) n-butanol, reflux;

DOI:10.1021/jm00121a022

Reference yield:

N-benzyl isonipecotic acid ethyl ester (24228-40-8) → 4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-N,N-dimethyl-benzamide; compound with (E)-but-2-enedioic acid (117023-73-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 65 percent / 1) Na₂CO₃, KI / 1) n-butanol, reflux

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00121a022

Reference yield:

α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol (111627-25-9) → 4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-N,N-dimethyl-benzamide; compound with (E)-but-2-enedioic acid (117023-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

2: 65 percent / 1) Na₂CO₃, KI / 1) n-butanol, reflux

With hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00121a022

upstream raw materials:

1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

(2E)-but-2-enedioic acid

4-(3-Chloro-propoxy)-N,N-dimethyl-benzamide

4-hydroxy-N,N-dimethyl-benzamide