1-(Prop-2-yn-1-yl)pyrrolidine-2,5-dione

Base Information

• Chemical Name: 1-(Prop-2-yn-1-yl)pyrrolidine-2,5-dione
• CAS No.: 10478-33-8
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.138
• European Community (EC) Number: 808-203-3
• DSSTox Substance ID: DTXSID10406130
• Nikkaji Number: J1.033.810G
• Wikidata: Q82211022
• Mol file: 10478-33-8.mol

Synonyms:10478-33-8;1-(Prop-2-yn-1-yl)pyrrolidine-2,5-dione;1-prop-2-ynylpyrrolidine-2,5-dione;N-propargylsuccinimide;N-(2-Propynyl)succinimide;2,5-Pyrrolidinedione, 1-(2-propynyl)-;SBB039933;SCHEMBL11726006;DTXSID10406130;DOTAQRZGKATJIC-UHFFFAOYSA-N;MFCD06740819;1-prop-2-ynyl-pyrrolidine-2,5-dione;AKOS000271351;AS-63040;CS-0440190;FT-0735332;P2191;C14080;F3250-0645

Chemical Property of 1-(Prop-2-yn-1-yl)pyrrolidine-2,5-dione

Chemical Property:

• Melting Point: 51.0 to 55.0 °C
• Boiling Point: 237°C(lit.)
• PSA: 37.38000
• LogP: -0.29350
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.047678466
• Heavy Atom Count: 10
• Complexity: 207

Purity/Quality:

97% ^*data from raw suppliers

N-(2-Propynyl)succinimide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C#CCN1C(=O)CCC1=O

Technology Process of 1-(Prop-2-yn-1-yl)pyrrolidine-2,5-dione

There total 8 articles about 1-(Prop-2-yn-1-yl)pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

succinic acid (110-15-6) + Propargylamine (2450-71-7) → 1-(prop-2-yn-1-yl)pyrrolidine-2,5-dione (10478-33-8)

Guidance literature:

With niobium(V) oxide; In hexane; for 10h; Inert atmosphere; Reflux;

DOI:10.1002/chem.201404538

Reference yield: 97.0%

Succinimide (123-56-8,89963-74-6) + propargyl bromide (106-96-7) → 1-(prop-2-yn-1-yl)pyrrolidine-2,5-dione (10478-33-8)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Heating;

DOI:10.1016/0040-4039(95)01158-e

Reference yield: 85.0%

5-ethenyl-5-hydroxy-1-propargyl-2-pyrrolidinone (170697-90-2) → 1-(prop-2-yn-1-yl)pyrrolidine-2,5-dione (10478-33-8)

Guidance literature:

With tin(IV) chloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/0040-4039(95)01158-e

upstream raw materials:

Succinimide

propargyl alcohol

propargyl bromide

5-ethenyl-5-hydroxy-1-propargyl-2-pyrrolidinone

Downstream raw materials:

1-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-but-2-ynyl]-pyrrolidine-2,5-dione