Glycine, N,N-diethyl-, ethyl ester

Base Information

• Chemical Name: Glycine, N,N-diethyl-, ethyl ester
• CAS No.: 2644-21-5
• Molecular Formula: C8H17 N O2
• Molecular Weight: 159.228
• European Community (EC) Number: 220-151-8
• DSSTox Substance ID: DTXSID00181025
• Nikkaji Number: J192.166E
• Mol file: 2644-21-5.mol

Synonyms:ethyl 2-(diethylamino)acetate;2644-21-5;Ethyl N,N-diethylaminoacetate;Glycine, N,N-diethyl-, ethyl ester;N,N-Diethylglycine ethyl ester;Ethyl N,N-diethylglycinate;Ethyl (diethylamino)acetate;EINECS 220-151-8;BRN 1759076;3-04-00-01135 (Beilstein Handbook Reference);ETHYLN,N-DIETHYLAMINOACETATE;ethyl2-(diethylamino)acetate;Ethyl (diethylamino)acetate #;SCHEMBL708934;DTXSID00181025;diethylamino acetic acid ethylester;ADAL1185320;CAA64421;STL301712;AKOS005188279;LS-72479;CS-0205225;FT-0634426

Chemical Property of Glycine, N,N-diethyl-, ethyl ester

Chemical Property:

• Vapor Pressure: 0.613mmHg at 25°C
• Boiling Point: 188°Cat760mmHg
• Flash Point: 61.8°C
• PSA: 29.54000
• Density: 0.929g/cm³
• LogP: 0.89130
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 159.125928785
• Heavy Atom Count: 11
• Complexity: 111

Purity/Quality:

98%Min ^*data from raw suppliers

ETHYL-N,N-DIETHYLAMINOACETATE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CC(=O)OCC

Technology Process of Glycine, N,N-diethyl-, ethyl ester

There total 16 articles about Glycine, N,N-diethyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diazoacetic acid ethyl ester (623-73-4) + diethylamine (109-89-7) → ethyl N,N-diethylglycinate (2644-21-5)

Guidance literature:

With acetone; In toluene; at 20 ℃; for 0.05h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c6cc10005h

Reference yield: 87.0%

chloroacetic acid ethyl ester (105-39-5) + diethylamine (109-89-7) → ethyl N,N-diethylglycinate (2644-21-5)

Guidance literature:

With sodium carbonate; potassium iodide; In acetone; for 6h; Heating;

Reference yield: 80.0%

ethyl bromoacetate (105-36-2) + diethylamine (109-89-7) → ethyl N,N-diethylglycinate (2644-21-5)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1002/anie.202106412

upstream raw materials:

diazoacetic acid ethyl ester

triethylamine

Triethylammoniumessigsaeure-betain

triethyl-carboxymethyl-ammonium; hydroxide

Downstream raw materials:

ethyl bromoacetate

5-[(N,N-diethyl-glycyl)-amino]-2-hydroxy-benzoic acid methyl ester

2-(diethylamino)acetylhydrazide

2-(diethylamino)acetic acid

Refernces

• 1、 Chen, Lianfen,Cui, Hao,Wang, Yanhu,Liang, Xiang,Zhang, Li,Su, Cheng-Yong. "Carbene insertion into N-H bonds with size-selectivity induced by a microporous ruthenium-porphyrin metal-organic framework". supporting information. p. 3940 - 3946. Retrieved 2018/03/21.
• 2、 Sumino, Shuhei,Fusano, Akira,Fukuyama, Takahide,Ryu, Ilhyong. "Synthesis of carbamoylacetates from α-iodoacetate, CO, and amines under Pd/light combined conditions". experimental part. p. 1331 - 1334. Retrieved 2012/07/13.