Benzyloxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

Base Information

Chemical Name:Benzyloxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester
CAS No.:75319-99-2
Molecular Formula:C₃₀H₂₅Cl₂N₃O₆
Molecular Weight:594.451
Hs Code.:

Synonyms:Benzyloxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

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Chemical Property of Benzyloxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

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Technology Process of Benzyloxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

There total 2 articles about Benzyloxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 75319-99-2
Benzyloxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CHCl₃; dimethylformamide; ethyl acetate / 1 h / 20 °C

2: dimethylformamide; CHCl₃; ethyl acetate / 45 h / 20 °C

With thionyl chloride; In chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00186a030

Reference yield:

: 15050-24-5
N-(benzyloxycarbonyl)glycyl chloride

: 75319-92-5
2-(2'-hydroxyethyl)-4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one

: 75319-99-2
Benzyloxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

Guidance literature:: In chloroform; ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 45h; Yield given;
DOI:10.1021/jm00186a030

Reference yield:

: 75319-99-2
Benzyloxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

: Amino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; at 20 ℃; for 16h; under 775.7 Torr;
DOI:10.1021/jm00186a030