N-Methoxy-N-methylbutanamide

Base Information

• Chemical Name: N-Methoxy-N-methylbutanamide
• CAS No.: 109480-78-6
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• Hs Code.: 2924199090
• Mol file: 109480-78-6.mol

Synonyms:N-methoxy-N-methyl-n-butylamide;N-Methoxy-N-methylbutyramide;N-methyl-N-methoxybutanamide;Butanamide,N-methoxy-N-methyl;N-methyl-N-methoxybutyramide;

Chemical Property of N-Methoxy-N-methylbutanamide

Chemical Property:

• Refractive Index: 1.4300 to 1.4340
• Boiling Point: 144.1±23.0 °C(Predicted)
• PSA: 29.54000
• Density: 0.948±0.06 g/cm3(Predicted)
• LogP: 0.80630
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Chloroform, Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methoxy-N-methylbutanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methoxy-N-methylbutanamide

There total 5 articles about N-Methoxy-N-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

butyryl chloride (141-75-3) + N,0-dimethylhydroxylamine (1117-97-1) → N-methoxy-N-methylbutanamide (109480-78-6)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ml4003925

Reference yield: 89.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + butyryl chloride (141-75-3) → N-methoxy-N-methylbutanamide (109480-78-6)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 3.5h;

DOI:10.1002/1521-3765(20011105)7:21<4562::AID-CHEM4562>3.0.CO;2-4

Reference yield: 89.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 4-Chlorobutanoyl chloride (4635-59-0) → N-methoxy-N-methylbutanamide (109480-78-6)

Guidance literature:

N,O-dimethylhydroxylamine*hydrochloride; With pyridine; at 0 ℃; for 0.166667h;

4-Chlorobutanoyl chloride; In dichloromethane; for 0.583333h;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

butyryl chloride

4-Chlorobutanoyl chloride

N,0-dimethylhydroxylamine

Downstream raw materials:

1-[2-(tert-Butoxycarbonylamino)-5-methoxyphenyl]-2-pentanone

1-[2-(tert-butoxycarbonylamino)-6-methoxyphenyl]-2-pentanone

4'-(2-butyl-benzofuran-3-yl)-biphenyl-4-ol

N-methylbutyramide

Refernces

• 1、 Terada, Masahiro,Li, Feng,Toda, Yasunori. "Chiral silver phosphate catalyzed transformation of ortho-alkynylaryl ketones into 1H-isochromene derivatives through an intramolecular-cyclization/ enantioselective-reduction sequence". . p. 235 - 239. Retrieved 2014.
• 2、 Tan, Xuefeng,Wen, Jialin,Zeng, Weijun,Zhang, Xumu. "Iridium-Catalyzed Asymmetric Hydrogenation of α-Fluoro Ketones via a Dynamic Kinetic Resolution Strategy". supporting information. p. 7230 - 7233. Retrieved 2020/10/02.
• 3、 -. "CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE". Paragraph 000458; 000459. . Retrieved 2018/01/17.