methyl 4-fluoro-1H-indole-2-carboxylate

Base Information

Chemical Name:methyl 4-fluoro-1H-indole-2-carboxylate
CAS No.:113162-36-0
Molecular Formula:C10H8FNO2
Molecular Weight:193.177
Hs Code.:2933998090
European Community (EC) Number:850-954-4
DSSTox Substance ID:DTXSID90405863
Wikidata:Q82210588
Mol file:113162-36-0.mol

Synonyms:methyl 4-fluoro-1H-indole-2-carboxylate;113162-36-0;1H-Indole-2-carboxylic acid, 4-fluoro-, methyl ester;MFCD06653401;4-fluoro-1H-indole-2-carboxylic acid methyl ester;1H-Indole-2-carboxylic acid, 4-floro-, Methyl ester;SCHEMBL2323348;DTXSID90405863;JXXLBPLHQYAPLH-UHFFFAOYSA-N;BBL022471;STK504660;AKOS000124003;SB14984;methyl4-fluoro-1H-indole-2-carboxylate;DS-17801;SY112391;CS-0030010;4-Fluoroindole-2-carboxylic acid methyl ester;EN300-30755;F52675;A894470;Z316185864

Suppliers and Price of methyl 4-fluoro-1H-indole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl4-Fluoro-1H-indole-2-carboxylate
500mg
$ 200.00

SynQuest Laboratories
Methyl 4-fluoro-1H-indole-2-carboxylate
1 g
$ 320.00

Matrix Scientific
Methyl 4-fluoro-1H-indole-2-carboxylate
500mg
$ 114.00

Crysdot
Methyl4-fluoro-1H-indole-2-carboxylate 95+%
1g
$ 186.00

Chemenu
Methyl4-fluoro-1H-indole-2-carboxylate 95%
1g
$ 180.00

Apolloscientific
Methyl4-fluoro-1H-indole-2-carboxylate
1g
$ 200.00

American Custom Chemicals Corporation
METHYL-4-FLUORO-1H-INDOLE-2-CARBOXYLATE 95.00%
5G
$ 1548.26

American Custom Chemicals Corporation
METHYL-4-FLUORO-1H-INDOLE-2-CARBOXYLATE 95.00%
2.5G
$ 1227.82

American Custom Chemicals Corporation
METHYL-4-FLUORO-1H-INDOLE-2-CARBOXYLATE 95.00%
1G
$ 852.55

Ambeed
Methyl4-fluoro-1H-indole-2-carboxylate 95+%
25g
$ 1951.00

Total 15 raw suppliers

Chemical Property of methyl 4-fluoro-1H-indole-2-carboxylate

Chemical Property:

Boiling Point:335.3±22.0 °C(Predicted)
PKA:14.37±0.30(Predicted)
PSA：42.09000
Density:1.341±0.06 g/cm3(Predicted)
LogP:2.09360
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:193.05390666
Heavy Atom Count:14
Complexity:234

Purity/Quality:

99%, ^*data from raw suppliers

Methyl4-Fluoro-1H-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CC2=C(N1)C=CC=C2F

Technology Process of methyl 4-fluoro-1H-indole-2-carboxylate

There total 8 articles about methyl 4-fluoro-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1816-92-8
Methyl azidoacetate

: 446-52-6
2-Fluorobenzaldehyde

: 113162-36-0
4-fluoro-1H-indole-2-carboxylic acid methyl ester

Guidance literature:: Methyl azidoacetate; 2-Fluorobenzaldehyde; With sodium methylate; In methanol; at -20 - 4 ℃; for 14h;

In xylene; Further stages.; Heating;
DOI:10.1080/15257770701505220

Reference yield: 66.7%

: 67-56-1
methanol

: 1816-92-8
Methyl azidoacetate

: 446-52-6
2-Fluorobenzaldehyde

: 113162-36-0
4-fluoro-1H-indole-2-carboxylic acid methyl ester

Guidance literature:: methanol; Methyl azidoacetate; 2-Fluorobenzaldehyde; With sodium methylate; at -20 - 4 ℃; for 14h;

In xylene; Further stages.; Heating;
DOI:10.1139/V07-020

Reference yield:

: 769-10-8
1-fluoro-2-methyl-3-nitrobenzene

: 113162-36-0
4-fluoro-1H-indole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: EtOK / ethanol / 6 h / Heating

2: aq. HCl

3: 62 percent / FeSO₄/NH₃

With hydrogenchloride; potassium ethoxide; ammonia; iron(II) sulfate; In ethanol;
DOI:10.1021/jm00400a009