Phosphonium, (2-methoxyethyl)triphenyl-, bromide

Base Information

• Chemical Name: Phosphonium, (2-methoxyethyl)triphenyl-, bromide
• CAS No.: 55894-16-1
• Molecular Formula: C21H22OP+
• Molecular Weight: 401.283
• Mol file: 55894-16-1.mol

Synonyms:2-methoxyethyl(triphenyl)phosphanium,bromide;

Chemical Property of Phosphonium, (2-methoxyethyl)triphenyl-, bromide

Chemical Property:

• Melting Point: 216 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 22.82000
• Density: g/cm³
• LogP: 0.63090
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

(2-METHOXY-ETHYL)-TRIPHENYL-PHOSPHONIUM, BROMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2-Methoxyethyl)triphenylphosphonium Bromide is an intermediate for the synthesis of (Z)-Triprolidine Oxalate Salt (T814007), which is an antihistaminic agent with anticholinergic properties. Triprolidine is used to treat and prevent symptoms associated with allergies. Triprolidine is also used in combination with cold medicine to provide relief for flu-like symptoms.

Technology Process of Phosphonium, (2-methoxyethyl)triphenyl-, bromide

There total 4 articles about Phosphonium, (2-methoxyethyl)triphenyl-, bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

triphenylphosphine (603-35-0) + 2-Bromoethyl methyl ether (6482-24-2) → (2-methoxyethyl)triphenylphosphonium bromide (55894-16-1)

Guidance literature:

In toluene; for 24h; Heating;

DOI:10.1016/j.tetlet.2007.11.182

Reference yield: 98.0%

methanol (67-56-1) + triphenylphosphine (603-35-0) + 2-bromoethanol (540-51-2) → (2-methoxyethyl)triphenylphosphonium bromide (55894-16-1)

Guidance literature:

at 100 ℃; sealed tube;

DOI:10.1016/S0040-4039(02)02155-X

Reference yield: 70.0%

methanol (67-56-1) + 2-(hydroxyethyl)triphenylphosphonium bromide (7237-34-5) → (2-methoxyethyl)triphenylphosphonium bromide (55894-16-1)

Guidance literature:

With potassium hydroxide; at 65 ℃; for 24h;

upstream raw materials:

methanol

2-(hydroxyethyl)triphenylphosphonium bromide

triphenylphosphine

2-bromoethanol

Downstream raw materials:

cinnamyl ethyl ether

[2-(dimethylamino)ethyl]triphenylphosphonium bromide

[2-(N-piperidino)ethyl]triphenylphosphonium bromide

[2-(N-morpholino)ethyl]triphenylphosphonium bromide

Refernces

• 1、 Rao, G. Venkateswara,Reddy, G. Chandrasekara. "Synthesis of 2-(N-disubstituted amino)ethyltriphenylphosphonium bromides". . p. 824 - 826. Retrieved 2008/04/13.
• 2、 -. "4-PHENYLPIPERIDINE DERIVATIVES AS RENIN INHIBITORS". Page/Page column 68. . Retrieved 2008/06/13.