AKOS AU36-M255

Base Information

• Chemical Name: AKOS AU36-M255
• CAS No.: 2982-53-8
• Molecular Formula: C11H13 N O6
• Molecular Weight: 255.227
• Mol file: 2982-53-8.mol

Synonyms:Aceticacid, (4,5-dimethoxy-2-nitrophenyl)-, methyl ester (6CI,7CI,8CI); NSC 225030

Chemical Property of AKOS AU36-M255

Chemical Property:

• Vapor Pressure: 6.76E-06mmHg at 25°C
• Boiling Point: 377.4°Cat760mmHg
• Flash Point: 165.1°C
• PSA: 90.58000
• Density: 1.262g/cm³
• LogP: 1.85070
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl (4,5-dimethoxy-2-nitrophenyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS AU36-M255

There total 5 articles about AKOS AU36-M255 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

methanol (67-56-1) + (4,5-dimethoxy-2-nitrophenyl)acetic acid (73357-18-3) → methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate (2982-53-8)

Guidance literature:

With sulfuric acid; at 40 ℃; Inert atmosphere;

DOI:10.1021/acschemneuro.7b00378

Reference yield: 64.0%

methyl (3,4-dimethoxyphenyl)acetate (15964-79-1) → methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate (2982-53-8)

Guidance literature:

With nitric acid; acetic acid; at -30 ℃;

DOI:10.1016/S0960-894X(98)00689-1

Reference yield:

2-(4,5-dimethoxy-2-nitrophenyl)ethan-1-ol (73357-23-0) → methyl 2-(4,5-dimethoxy-2-nitrophenyl)acetate (2982-53-8)

Guidance literature:

With hydrogenchloride; sodium borohydrid; sodium hydrogencarbonate; In tetrahydrofuran; methanol; hexane;

upstream raw materials:

methyl (3,4-dimethoxyphenyl)acetate

methanol

(4,5-dimethoxy-2-nitrophenyl)acetic acid

(3,4-Dimethoxyphenyl)acetic acid

Downstream raw materials:

2-(4,5-dimethoxy-2-nitrophenyl)ethan-1-ol

methyl 2-(4,5-dimethoxy-2-nitrophenyl)acrylate

2-nitro-4,5-dimethoxyphenethyl methanesulfonate

2-nitro-4,5-dimethoxy-N-methylphenethylamine

Refernces

• 1、 Lewin, Anita H.,Fix, Scott E.,Zhong, Desong,Mayer, Louise D.,Burgess, Jason P.,Mascarella, S. Wayne,Reddy, P. Anantha,Seltzman, Herbert H.,Carroll, F. Ivy. "Caged Naloxone: Synthesis, Characterization, and Stability of 3- O -(4,5-Dimethoxy-2-nitrophenyl)carboxymethyl Naloxone (CNV-NLX)". . p. 563 - 567. Retrieved 2018/03/27.
• 2、 -. "Amine derivatives, processes for producing them and a use of them as antiarrhythmic drugs". . . Retrieved 2008/06/13.