racemic-2,3-Diethylbutanedioic acid

Base Information

• Chemical Name: racemic-2,3-Diethylbutanedioic acid
• CAS No.: 35392-77-9
• Molecular Formula: C₈H₁₄O₄
• Molecular Weight: 174.197
• Mol file: 35392-77-9.mol

Synonyms:

Chemical Property of racemic-2,3-Diethylbutanedioic acid

Chemical Property:

• Boiling Point: 274°Cat760mmHg
• Flash Point: 133.7°C
• Density: 1.156g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of racemic-2,3-Diethylbutanedioic acid

There total 19 articles about racemic-2,3-Diethylbutanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

tetrachloromethane (56-23-5) + butyric acid (107-92-6) → 2-chlorobutanoic acid (4170-24-5) + meso-2,3-diethylsuccinic acid (35392-80-4) + (±)-2,3-diethylsuccinic acid (1186-79-4,35392-77-9,35392-80-4,62016-50-6,72002-62-1) + chloroform (67-66-3,8013-54-5)

Guidance literature:

butyric acid; With lithium diisopropyl amide; In tetrahydrofuran; at 0 - 40 ℃; Inert atmosphere;

tetrachloromethane; In tetrahydrofuran; at 20 - 25 ℃; for 2h; Inert atmosphere;

DOI:10.1134/S1070428019010068

Reference yield:

1-hexene (592-41-6,25067-06-5) + ethylene dibromide (106-93-4) + butyric acid (107-92-6) → ethyl bromide (74-96-4) + meso-2,3-diethylsuccinic acid (35392-80-4) + (±)-2,3-diethylsuccinic acid (1186-79-4,35392-77-9,35392-80-4,62016-50-6,72002-62-1) + 1-bromo-octane (111-83-1)

Guidance literature:

butyric acid; With lithium diisopropyl amide; In tetrahydrofuran; at 0 - 40 ℃; Inert atmosphere;

1-hexene; ethylene dibromide; In tetrahydrofuran; at 20 - 25 ℃; for 2h;

DOI:10.1134/S1070363215060043

Reference yield:

butyric acid (107-92-6) → meso-2,3-diethylsuccinic acid (35392-80-4) + (±)-2,3-diethylsuccinic acid (1186-79-4,35392-77-9,35392-80-4,62016-50-6,72002-62-1)

Guidance literature:

butyric acid; With lithium diisopropyl amide; In tetrahydrofuran; at 0 - 40 ℃; for 0.666667h; Inert atmosphere;

With 1,2-Diiodoethane; In tetrahydrofuran; at 35 - 40 ℃; for 2h; Overall yield = 53 %; Inert atmosphere;

DOI:10.1134/S1070363219010262

upstream raw materials:

diacetyl peroxide

butyric acid

Diethyl ethylsodiomalonate

2-bromobutyric acid ethyl ester

Downstream raw materials:

3,3-diethyldihydrofuran-2,5-dione