5-(3,3-dimethyl-but-1-ynyl)-3-[(1,4-dioxa-spiro[4.5]dec-8-yl)-((1R)-4-methyl-cyclohex-3-ene carbonyl)-amino]thiophene-2-carboxylic acid methyl ester

Base Information

Chemical Name:5-(3,3-dimethyl-but-1-ynyl)-3-[(1,4-dioxa-spiro[4.5]dec-8-yl)-((1R)-4-methyl-cyclohex-3-ene carbonyl)-amino]thiophene-2-carboxylic acid methyl ester
CAS No.:1384122-54-6
Molecular Formula:C₂₈H₃₇NO₅S
Molecular Weight:499.671
Hs Code.:

Synonyms:5-(3,3-dimethyl-but-1-ynyl)-3-[(1,4-dioxa-spiro[4.5]dec-8-yl)-((1R)-4-methyl-cyclohex-3-ene carbonyl)-amino]thiophene-2-carboxylic acid methyl ester

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Chemical Property of 5-(3,3-dimethyl-but-1-ynyl)-3-[(1,4-dioxa-spiro[4.5]dec-8-yl)-((1R)-4-methyl-cyclohex-3-ene carbonyl)-amino]thiophene-2-carboxylic acid methyl ester

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Technology Process of 5-(3,3-dimethyl-but-1-ynyl)-3-[(1,4-dioxa-spiro[4.5]dec-8-yl)-((1R)-4-methyl-cyclohex-3-ene carbonyl)-amino]thiophene-2-carboxylic acid methyl ester

There total 9 articles about 5-(3,3-dimethyl-but-1-ynyl)-3-[(1,4-dioxa-spiro[4.5]dec-8-yl)-((1R)-4-methyl-cyclohex-3-ene carbonyl)-amino]thiophene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1263101-80-9
5-(3,3-dimethyl-but-1-ynyl)-3-(1,4-dioxa-spiro[4.5]dec-8-ylamino)-thiophene-2-carboxylic acid methyl ester

: 1314795-37-3
(1R)-4-methylcyclohex-3-enecarboxylic acid chloride

: 1384122-54-6
5-(3,3-dimethyl-but-1-ynyl)-3-[(1,4-dioxa-spiro[4.5]dec-8-yl)-((1R)-4-methyl-cyclohex-3-ene carbonyl)-amino]thiophene-2-carboxylic acid methyl ester

Guidance literature:: With potassium phosphate; In dichloromethane; at 80 ℃; for 6h; Inert atmosphere;
DOI:10.1021/jm401420j

Reference yield:

: 1384122-49-9
(R)-((S)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl) 4-methylcyclohex-3-ene carboxylate

: 1384122-54-6
5-(3,3-dimethyl-but-1-ynyl)-3-[(1,4-dioxa-spiro[4.5]dec-8-yl)-((1R)-4-methyl-cyclohex-3-ene carbonyl)-amino]thiophene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 50 °C

2: potassium phosphate; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

3: potassium phosphate / 1,2-dichloro-ethane / 16 h / 90 °C / Sealed tube

With potassium phosphate; oxalyl dichloride; water; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 121424-36-0
(+)-(1R)-4-methyl-cyclohex-3-enecarboxylic acid

: 1384122-54-6
5-(3,3-dimethyl-but-1-ynyl)-3-[(1,4-dioxa-spiro[4.5]dec-8-yl)-((1R)-4-methyl-cyclohex-3-ene carbonyl)-amino]thiophene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; potassium phosphate / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2: potassium phosphate / dichloromethane / 6 h / 80 °C / Inert atmosphere

With potassium phosphate; oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401420j