tert-Butyl 3-methylidenecyclobutane-1-carboxylate

Base Information

Chemical Name:tert-Butyl 3-methylidenecyclobutane-1-carboxylate
CAS No.:122699-51-8
Molecular Formula:C10H16O2
Molecular Weight:168.236
Hs Code.:
European Community (EC) Number:962-779-1
DSSTox Substance ID:DTXSID00560210
Wikidata:Q82443216
Mol file:122699-51-8.mol

Synonyms:122699-51-8;tert-Butyl 3-methylidenecyclobutane-1-carboxylate;tert-butyl 3-methylenecyclobutanecarboxylate;Cyclobutanecarboxylic acid, 3-methylene-, 1,1-dimethylethyl ester;3-Methylene-cyclobutanecarboxylic acid tert-butyl ester;tert-Butyl 3-methylenecyclobutane-1-carboxylate;SCHEMBL15167444;DTXSID00560210;MFCD26402411;AT10153;SB32012;PS-19398;SY288681;EN300-187607

Suppliers and Price of tert-Butyl 3-methylidenecyclobutane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of tert-Butyl 3-methylidenecyclobutane-1-carboxylate

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:168.115029749
Heavy Atom Count:12
Complexity:202

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)C1CC(=C)C1

Technology Process of tert-Butyl 3-methylidenecyclobutane-1-carboxylate

There total 1 articles about tert-Butyl 3-methylidenecyclobutane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15760-35-7
3-methylenecyclobutanecarbonitrile

: 122699-51-8
3-methylenecyclobutanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol; water / 105 °C

2: dmap / tetrahydrofuran / 20 °C

With dmap; potassium hydroxide; In tetrahydrofuran; ethanol; water;

Reference yield:

: 1373278-09-1
methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.

: 122699-51-8
3-methylenecyclobutanecarboxylic acid tert-butyl ester

: 1373278-85-3
methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

Guidance literature:: 3-methylenecyclobutanecarboxylic acid tert-butyl ester; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 0 - 60 ℃; for 3h; Inert atmosphere;

methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.; With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; at 60 ℃; for 12h; Inert atmosphere;

Reference yield:

: 122699-51-8
3-methylenecyclobutanecarboxylic acid tert-butyl ester

: tert-butyl 1-(2'-(phenylseleno)ethyl)-3-methylenecyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium diisopropylamide (LDA), HMPA / 1.) THF, -70 deg C, 20 min, 2.) THF, from -70 deg C to RT

2: 92 percent / NaBH₄ / ethanol / 70 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; lithium diisopropyl amide; In ethanol;
DOI:10.1021/jo00281a043