Decanoic acid, 3-hydroxy-, ethyl ester, (R)-

Base Information

Chemical Name:Decanoic acid, 3-hydroxy-, ethyl ester, (R)-
CAS No.:130322-00-8
Molecular Formula:C12H24O3
Molecular Weight:216.321
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Decanoic acid, 3-hydroxy-, ethyl ester, (R)-

Chemical Property:

Purity/Quality:

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Technology Process of Decanoic acid, 3-hydroxy-, ethyl ester, (R)-

There total 3 articles about Decanoic acid, 3-hydroxy-, ethyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13195-66-9
ethyl 3-oxodecanoate

: 821-55-6
2-Nonanone

: 130322-00-8
ethyl (R)-3-hydroxydecanoate

: 214193-71-2
(S)-3-Hydroxy-decanoic acid ethyl ester

Guidance literature:: In water; at 27 ℃; for 24h; Title compound not separated from byproducts; Geotrichum candidum;
DOI:10.1016/S0957-4166(00)86143-1

Reference yield:

: 64-17-5
ethanol

: 66696-94-4
benzyl 3-oxodecanoate

: 130322-00-8
ethyl (R)-3-hydroxydecanoate

: benzyl (R)-3-hydroxydecanoate

Guidance literature:: With hydrogen; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; at 115 ℃; for 72h; under 2327.23 Torr; enantioselective reaction;
DOI:10.1021/jacs.7b00427

Reference yield:

: 111-64-8
n-octanoic acid chloride

: 130322-00-8
ethyl (R)-3-hydroxydecanoate

: benzyl (R)-3-hydroxydecanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

1.3: 3 h / Reflux; Inert atmosphere

2.1: hydrogen; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / 72 h / 115 °C / 2327.23 Torr

With pyridine; hydrogen; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In tetrahydrofuran; 2.1: |Noyori Asymmetric Hydrogenation;
DOI:10.1021/jacs.7b00427