2-(1,4-Dioxaspiro[4.5]decan-8-yl)acetic acid

Base Information

Chemical Name:2-(1,4-Dioxaspiro[4.5]decan-8-yl)acetic acid
CAS No.:134136-04-2
Molecular Formula:C10H16O4
Molecular Weight:200.235
Hs Code.:2932999099
European Community (EC) Number:829-270-5
DSSTox Substance ID:DTXSID90568205
Wikidata:Q82454382
Mol file:134136-04-2.mol

Synonyms:134136-04-2;1,4-Dioxaspiro[4.5]decane-8-acetic acid;2-(1,4-Dioxaspiro[4.5]decan-8-yl)acetic acid;2-{1,4-dioxaspiro[4.5]decan-8-yl}acetic acid;(1,4-Dioxa-spiro[4.5]dec-8-yl)-acetic acid;1,4-Dioxa-spiro[4.5]dec-8-yl)-acetic acid;(1,4-Dioxaspiro[4.5]dec-8-yl)-acetic acid;(1,4-Dioxaspiro[4.5]decan-8-yl)acetic acid;SCHEMBL2450101;DTXSID90568205;RDZCSTLPRXANJV-UHFFFAOYSA-N;AB7088;MFCD16620931;AKOS022919117;AB89948;BS-25642;1,4-Dioxaspiro[4,5]decane-8-acetic acid;1,4-Dioxaspiro[4.5]dec-8-yl-acetic acid;1,4-Dioxa-spiro[4.5]dec-8-yl-acetic acid;CS-0342652;EN300-151755;2-(1,4-Dioxaspiro[4.5]decan-8-yl)aceticacid;A906429;A1-08481;F8888-3808;Z1269223588

Suppliers and Price of 2-(1,4-Dioxaspiro[4.5]decan-8-yl)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,4-Dioxaspiro[4.5]decane-8-aceticAcid
50mg
$ 90.00

Matrix Scientific
1,4-Dioxaspiro[4.5]dec-8-yl-acetic acid 95%
5g
$ 1320.00

Crysdot
2-(1,4-Dioxaspiro[4.5]decan-8-yl)aceticacid 95+%
5g
$ 1216.00

Crysdot
2-(1,4-Dioxaspiro[4.5]decan-8-yl)aceticacid 95+%
1g
$ 347.00

Chemenu
2-(1,4-dioxaspiro[4.5]decan-8-yl)aceticacid 95%
1g
$ 327.00

Chemenu
2-(1,4-dioxaspiro[4.5]decan-8-yl)aceticacid 95%
5g
$ 1146.00

Apolloscientific
1,4-Dioxaspiro[4.5]decane-8-aceticacid
5g
$ 2828.00

Alichem
2-(1,4-Dioxaspiro[4.5]decan-8-yl)aceticacid
1g
$ 346.50

Alichem
2-(1,4-Dioxaspiro[4.5]decan-8-yl)aceticacid
5g
$ 1286.25

AK Scientific
1,4-Dioxaspiro[4.5]decane-8-aceticacid
5g
$ 1491.00

Total 12 raw suppliers

Chemical Property of 2-(1,4-Dioxaspiro[4.5]decan-8-yl)acetic acid

Chemical Property:

Boiling Point:360.4±17.0 °C(Predicted)
PKA:4.69±0.10(Predicted)
PSA：55.76000
Density:1.21±0.1 g/cm3(Predicted)
LogP:1.39440
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:200.10485899
Heavy Atom Count:14
Complexity:210

Purity/Quality:

97% ^*data from raw suppliers

1,4-Dioxaspiro[4.5]decane-8-aceticAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2(CCC1CC(=O)O)OCCO2

Technology Process of 2-(1,4-Dioxaspiro[4.5]decan-8-yl)acetic acid

There total 5 articles about 2-(1,4-Dioxaspiro[4.5]decan-8-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 62141-26-8
ethyl 1,4-dioxaspiro[4.5]dec-8-ylacetate

: 134136-04-2
(1,4-dioxa-spiro[4.5]-dec-8-yl)-acetic acid

Guidance literature:: ethyl 1,4-dioxaspiro[4.5]dec-8-ylacetate; With sodium hydroxide; water; In ethanol; at 20 ℃;

With hydrogenchloride; In water;

Reference yield: 72.0%

: 64-18-6
formic acid

: 51656-90-7
8-methylene-1,4-dioxaspiro[4.5]decane

: 134136-04-2
(1,4-dioxa-spiro[4.5]-dec-8-yl)-acetic acid

Guidance literature:: With palladium diacetate; acetic anhydride; P(p-C₆H₄F)3; In toluene; at 90 ℃; for 48h; regioselective reaction; Sealed tube; Inert atmosphere;
DOI:10.1021/acs.orglett.9b02101

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 134136-04-2
(1,4-dioxa-spiro[4.5]-dec-8-yl)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol

3: water; potassium hydroxide / ethanol / 20 °C

With palladium 10% on activated carbon; water; hydrogen; sodium hydride; potassium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2010.12.060