Benzene, (4-ethyl-3-cyclohexen-1-yl)-

Base Information

• Chemical Name: Benzene, (4-ethyl-3-cyclohexen-1-yl)-
• CAS No.: 138624-02-9
• Molecular Formula: C14H18
• Molecular Weight: 186.297
• Mol file: 138624-02-9.mol

Synonyms:

Chemical Property of Benzene, (4-ethyl-3-cyclohexen-1-yl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, (4-ethyl-3-cyclohexen-1-yl)-

There total 7 articles about Benzene, (4-ethyl-3-cyclohexen-1-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-Phenyl-1-vinyl-1-cyclohexene (131111-08-5) → (4-Ethyl-cyclohex-3-enyl)-benzene (138624-02-9)

Guidance literature:

With 2,6-bis[1-(2,6-diisopropylphenylimino)ethyl]pyridine cobalt(II) dichloride; diethoxymethylane; sodium triethylborohydride; In neat (no solvent); at -78 - 40 ℃; for 1.08333h;

DOI:10.1021/acscatal.6b02272

Reference yield: 67.0%

4-phenylcyclohex-1-enyl trifluoromethanesulfonate (122948-47-4) + propionic acid anhydride (123-62-6) → (4-Ethyl-cyclohex-3-enyl)-benzene (138624-02-9)

Guidance literature:

With pyridine N-oxide; potassium fluoride; 1,10-Phenanthroline; lithium chloride; nickel dichloride; zinc; In N,N-dimethyl acetamide; at 0 ℃; for 72h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b01048

Reference yield:

1-phenyl-4-cyclohexanone (4894-75-1) → (4-Ethyl-cyclohex-3-enyl)-benzene (138624-02-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: nickel dichloride; 1,10-Phenanthroline; pyridine N-oxide; lithium chloride; potassium fluoride; zinc / N,N-dimethyl acetamide / 72 h / 0 °C / Inert atmosphere; Sealed tube

With pyridine N-oxide; potassium fluoride; 1,10-Phenanthroline; lithium chloride; nickel dichloride; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; N,N-dimethyl acetamide;

DOI:10.1021/acs.orglett.9b01048

upstream raw materials:

4-Phenyl-1-vinyl-1-cyclohexene

1-phenyl-4-cyclohexanone

4-phenylcyclohex-1-enyl trifluoromethanesulfonate

propionic acid anhydride