1-(2-chloroacetyl)-3-p-tolylurea

Base Information

• Chemical Name: 1-(2-chloroacetyl)-3-p-tolylurea
• CAS No.: 13558-77-5
• Molecular Formula: C10H11ClN2O2
• Molecular Weight: 226.663
• Hs Code.: 2924299090
• Mol file: 13558-77-5.mol

Synonyms:1-chloroacetyl-3-p-tolyl-urea;N-Chloracetyl-N'-<4-methyl-phenyl>-harnstoff;N-Chloracetyl-N'-p-tolyl-harnstoff;Acetamide,2-chloro-N-[[(4-methylphenyl)amino]carbonyl];N-(Chloroacetyl)-N'-(4-methylphenyl)urea;N-p-Tolyl-N'-chloracetyl-harnstoff;

Chemical Property of 1-(2-chloroacetyl)-3-p-tolylurea

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 58.20000
• Density: 1.313g/cm³
• LogP: 2.34580

Purity/Quality:

99% ^*data from raw suppliers

3-(2-chloroacetyl)-1-(4-methylphenyl)urea ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-chloroacetyl)-3-p-tolylurea

There total 5 articles about 1-(2-chloroacetyl)-3-p-tolylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

oxalyl dichloride (79-37-8) + p-toluidine (106-49-0,12221-03-3) + Chloroacetamide (79-07-2) → 1-chloroacetyl-3-p-tolyl-urea (13558-77-5)

Guidance literature:

oxalyl dichloride; Chloroacetamide; In 1,2-dichloro-ethane; at 0 - 90 ℃; for 4h;

p-toluidine; In 1,2-dichloro-ethane; at 0 ℃; for 0.0833333h;

DOI:10.3390/molecules25051138

Reference yield: 59.0%

2-chloroacetylisocyanate (4461-30-7) + p-toluidine (106-49-0,12221-03-3) → 1-chloroacetyl-3-p-tolyl-urea (13558-77-5)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2007.04.028

Reference yield:

Oxalamide (471-46-5) + p-toluidine (106-49-0,12221-03-3) + Chloroacetamide (79-07-2) → 1-chloroacetyl-3-p-tolyl-urea (13558-77-5)

Guidance literature:

In dichloromethane; at 0 ℃; for 6h; Reflux;

DOI:10.1248/cpb.c19-00359

upstream raw materials:

2-chloroacetylisocyanate

p-toluidine

p-tolylurea

chloroacetyl chloride

Downstream raw materials:

2-morpholin-4-yl-N-p-tolylcarbamoyl-acetamide

2-[5-(4-chloro-phenoxymethyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-N-p-tolylcarbamoyl-acetamide

2-[5-(2,4-dichloro-phenoxymethyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-N-p-tolylcarbamoyl-acetamide

Dithiophosphorsaeure-