Dimethyl morpholinophosphoramidate

Base Information

• Chemical Name: Dimethyl morpholinophosphoramidate
• CAS No.: 597-25-1
• Molecular Formula: C6H14 N O4 P
• Molecular Weight: 195.155
• Hs Code.: 2934999090
• European Community (EC) Number: 800-217-8
• UNII: D1B75YF8F1
• DSSTox Substance ID: DTXSID5020495
• Nikkaji Number: J15.440G
• Wikidata: Q27275969
• Mol file: 597-25-1.mol

Synonyms:dimethyl morpholinophosphoramidate;dimethylmorpholinophosphoramidate;DM-MP

Chemical Property of Dimethyl morpholinophosphoramidate

Chemical Property:

• Vapor Pressure: 0.0266mmHg at 25°C
• Boiling Point: 246.8°C at 760 mmHg
• Flash Point: 103.1°C
• PSA: 57.81000
• Density: 1.21g/cm³
• LogP: 0.65740
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 195.06604493
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

dimethyl(morpholin-4-yl)phosphonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Organophosphates, Other
• Canonical SMILES: COP(=O)(N1CCOCC1)OC

Technology Process of Dimethyl morpholinophosphoramidate

There total 4 articles about Dimethyl morpholinophosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl phosphite (96-36-6,868-85-9) + 4-(benzothiazole-2-sulfenyl)-morpholine (102-77-2) → N,N-oxydiethylene-O,O-dimethylphosphoramidate (597-25-1) + 2-Mercaptobenzothiazole (149-30-4,118090-09-8)

Guidance literature:

DOI:10.1246/cl.1980.695

Reference yield: 91.0%

4-(benzothiazole-2-sulfenyl)-morpholine (102-77-2) + phosphorous acid trimethyl ester (121-45-9) → 2-methylmercaptobenzothiazole (615-22-5) + N,N-oxydiethylene-O,O-dimethylphosphoramidate (597-25-1) + 2-Mercaptobenzothiazole (149-30-4,118090-09-8)

Guidance literature:

DOI:10.1246/cl.1980.695

Reference yield: 67.0%

4-(benzothiazole-2-sulfenyl)-morpholine (102-77-2) + phosphorous acid trimethyl ester (121-45-9) → 2-methylmercaptobenzothiazole (615-22-5) + N,N-oxydiethylene-O,O-dimethylphosphoramidate (597-25-1)

Guidance literature:

In toluene; for 0.33h; Yields of byproduct given; Ambient temperature;

upstream raw materials:

methyl phosphite

4-(benzothiazole-2-sulfenyl)-morpholine

phosphorous acid trimethyl ester

methanol