(R)-Ketamine

Base Information Edit

Chemical Name:(R)-Ketamine
CAS No.:33643-49-1
Molecular Formula:C₁₃H₁₆ClNO
Molecular Weight:237.729
Hs Code.:
UNII:Y2RI13H7VW
DSSTox Substance ID:DTXSID2048747
Nikkaji Number:J238.629A
Wikipedia:Arketamine
Wikidata:Q20707684
Metabolomics Workbench ID:67023
ChEMBL ID:CHEMBL467505
Mol file:33643-49-1.mol

Synonyms:(R)-Ketamine;arketamine;(+)-Ketamine;d-Ketamine;(R)-(+)-Ketamine;33643-49-1;Ketamine, R-;Ketamine, (R)-;Y2RI13H7VW;UNII-Y2RI13H7VW;J238.629A;(2R)-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one;DTXSID2048747;CHEBI:580604;(2R)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone;cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (2R)-;(2R)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone;Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+)-;(S) Ketamine;ARKETAMINE [WHO-DD];SCHEMBL16104;CHEMBL467505;GTPL9153;DTXCID9028673;PCN-101;Tox21_113205;NCGC00185909-01;CAS-33643-49-1;HR-071603;Q20707684;(2R)-2-(2-chlorophenyl)-2-methylaminocyclohexan-1-one;Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (R)-;Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (2R)- (9CI);Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+)- (8CI);RKE

Suppliers and Price of (R)-Ketamine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 18 raw suppliers

Chemical Property of (R)-Ketamine Edit

Chemical Property:

Vapor Pressure:1.76E-05mmHg at 25°C
Boiling Point:363.8°Cat760mmHg
PKA:6.46±0.20(Predicted)
Flash Point:173.8°C
PSA：29.10000
Density:1.17g/cm³
LogP:3.28870
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:237.0920418
Heavy Atom Count:16
Complexity:269

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC1(CCCCC1=O)C2=CC=CC=C2Cl
Isomeric SMILES:CN[C@]1(CCCCC1=O)C2=CC=CC=C2Cl
Recent ClinicalTrials:A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD
Recent EU Clinical Trials:A randomized, placebo-controlled, double-blind study to assess the safety and efficacy of intravenous PCN-101 in treatment-resistant depression
Recent NIPH Clinical Trials:Effects of single intravenous arketamine dose as adjunctive therapy for bipolar depression: a randomized, double-blind, crossover, placebo-controlled trial

Technology Process of (R)-Ketamine

There total 72 articles about (R)-Ketamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1867-66-9
(+/-)-ketamine hydrochloride

: 6740-88-1,100477-72-3,33643-46-8,33643-49-1
ketamine

Guidance literature:: With sodium hydroxide; In chloroform; water;

Reference yield: 90.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 35211-10-0,83777-65-5
norketamine

: 6740-88-1,100477-72-3,33643-46-8,33643-49-1
ketamine

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 12h;

Reference yield: 85.3%

: (±)-2-(2-chlorophenyl)-2-hydroxycyclohexan-1-one

: 74-89-5
methylamine

: 6740-88-1,100477-72-3,33643-46-8,33643-49-1
ketamine

Guidance literature:: (±)-2-(2-chlorophenyl)-2-hydroxycyclohexan-1-one; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at -5 - 0 ℃; for 1h; Inert atmosphere;

methylamine; In ethanol; at 15 - 20 ℃;
DOI:10.1021/acs.joc.0c01090