Refernces
10.1016/j.bmcl.2016.06.038
The study focuses on the synthesis, identification, and in vitro biological evaluation of novel quinoline-incorporated 1,3-thiazinan-4-one derivatives. Two new series of compounds, 3-hydroxy-N-(4-oxo-2-phenyl-1,3-thiazinan-3-yl)-8-(trifluoromethyl)quinoline-2-carboxamide derivatives (4a-j) and 3-((7-chloroquinolin-4-ylamino)methyl)-2-phenyl-1,3-thiazinan-4-one derivatives (5a-7j), were synthesized through a one-pot three-component cyclo-condensation reaction. These compounds were characterized using FT-IR, 1H, 13C NMR, and elemental analysis. Their in vitro biological activities were assessed for antibacterial effects against various pathogenic bacterial strains, antitubercular activity against Mycobacterium Tuberculosis H37Rv, and antimalarial activity against Plasmodium falciparum. The study identified certain compounds, particularly 4f and 5f, that exhibited excellent antibacterial and antitubercular activities, along with good antimalarial activity, comparing favorably with frontline drugs. The findings suggest potential for these compounds as new antimicrobial, antitubercular, and antimalarial agents.
10.1039/c3nj01308a
The research focuses on the synthesis, identification, and in vitro biological evaluation of novel quinoline-incorporated 1,3-thiazinan-4-one derivatives. The study describes the creation of two new series of compounds, (4a-j) and (5a-7j), through a one-pot three-component cyclo-condensation reaction, yielding products in moderate to good yields. The synthesis involved reactants such as 4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide, substituted benzaldehydes, 3-mercaptopropionic acid, and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC). The synthesized compounds were characterized using Fourier-transform infrared spectroscopy (FT-IR), proton and carbon-13 nuclear magnetic resonance (1H and 13C NMR), and elemental analysis to confirm their structures. The in vitro biological evaluation involved screening the compounds for antibacterial activity against both Gram-positive and Gram-negative bacteria, antitubercular activity against Mycobacterium Tuberculosis H37Rv, and antimalarial activity against Plasmodium falciparum. The results indicated that some compounds, particularly 4f and 5f, showed excellent antibacterial and antitubercular activity, while several others demonstrated good antimalarial activity, presenting potential as new antimicrobial, antitubercular, and antimalarial agents.
10.1039/b904863d
The study focuses on the design and synthesis of an oligothiophene molecule, 5TPY, which noncovalently functionalizes single-wall carbon nanotubes (SWNTs) to create a hybrid material for photovoltaic devices. The purpose of this hybrid material is to leverage the excellent electron transfer abilities of SWNTs, their flexibility, and optical transparency to potentially enhance the performance of flexible organic solar cells. The chemicals used in the study include pyrene as the CNT-binding group due to its ability to adsorb to carbon nanotubes through π-π stacking interactions, a quinquethiophene segment as the electronically active segment, and various reagents in the synthesis process such as 2-thiophenecarbonitrile, NBS (N-bromosuccinimide), TFA (Trifluoroacetic acid), 1-pyrenebutyric acid, DPTS (N,N'-Dicyclohexylcarbodiimide), EDCI (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide), and tributyltin compounds. These chemicals serve to construct the 5TPY molecule and facilitate its assembly around the SWNTs, preserving the electronic properties of the nanotubes for use in photovoltaic applications.
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