32897-26-0Relevant articles and documents
Reciprocal Coupling in Chemically Fueled Assembly: A Reaction Cycle Regulates Self-Assembly and Vice Versa
Kriebisch, Brigitte A. K.,Jussupow, Alexander,Bergmann, Alexander M.,Kohler, Fabian,Dietz, Hendrik,Kaila, Ville R. I.,Boekhoven, Job
, p. 20837 - 20844 (2020)
In biology, self-assembly of proteins and energy-consuming reaction cycles are intricately coupled. For example, tubulin is activated and deactivated for assembly by a guanosine triphosphate (GTP)-driven reaction cycle, and the emerging microtubules catalyze this reaction cycle by changing the microenvironment of the activated tubulin. Recently, synthetic analogs of chemically fueled assemblies have emerged, but examples in which assembly and reaction cycles are reciprocally coupled remain rare. In this work, we report a peptide that can be activated and deactivated for self-assembly. The emerging assemblies change the microenvironment of their building blocks, which consequently accelerate the rates of building block deactivation and reactivation. We quantitatively understand the mechanisms at play, and we are thus able to tune the catalysis by molecular design of the peptide precursor.
FUNCTIONALISING DIACETYLENE COMPOUNDS
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Page/Page column 26-29, (2020/03/02)
The invention relates to a method of functionalising a diacetylene compound of formula (II) to form a diacetylene compound of formula (I): wherein x is from 1 to 20; Q is selected from an amide having the formula (IV) and an ester having the formula (V) wherein R1 and R2 are each independently selected from hydrogen, a -(CH2)y-CH3 linear alkyl chain, a C1-20 alkene group, a C5-20 aryl group, a C1-20 alkoxy group, a hydroxyl C1-20 alkoxy group, a heteroaryl ring, a C3-18 cycloalkyl group, and (CH2)Z-E-P, and R3 is selected from a C1-20 alkyl group, a C1-20 alkene group, a C5-20 aryl group, a C1-20 alkoxy group, a hydroxyl C1-20 alkoxy group, a heteroaryl ring, a C3-18 cycloalkyl group, and (CH2)Z-E- P, and y is selected from 1 to 20, z is selected from 0 to 10, E may be present or absent, and when present, E is selected from NH, O, and CH2, and P is a protecting group; and T is selected from hydrogen, a -(CH2)y-CH3 linear alkyl chain, and - (CH2)X-Q wherein x, y and Q are as defined for formula (I); comprising the steps of reacting a diacetylene compound of formula (II) and a compound of formula (III): (II) (III) wherein T is selected from hydrogen, a -(CH2)y-CH3 linear alkyl chain, and - (CH2)x-COOH wherein x and y are as defined for formula (I); and L' is selected from NR1R2 and OR3 wherein R1, R2 and R3 are as defined for Q in formula (I); in the presence of a coupling reagent and optionally, a catalyst or base.
PHENOBARBITAL DERIVATIVES USEFUL IN IMMUNOASSAY
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Page/Page column 21, (2009/05/28)
Phenobarbital derivatives synthesized out of the alkyl chain at the 5-position, particularly with hydrophilic properties, and carrying an active ester at the end, allow formation of aminodextran conjugates that give curves in the desired range of the assay in the ONLINE TDM microparticle assay format when matched against the Roche FPIA antibody specific for phenobarbital ("an antibody specific for phenobarbital").
